Department of Neurology and the Sanders-Brown Center on Aging, 303 Sanders-Brown Building, 800 S. Limestone, University of Kentucky, Lexington, USA.
Curr Alzheimer Res. 2012 Jul;9(6):724-33. doi: 10.2174/156720512801322591.
Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.
自 1989 年以来，肯塔基大学已经招募了认知功能正常的老年研究志愿者，对他们进行纵向随访，并进行了广泛的神经病理学评估。迄今为止，该队列已经招募了 1030 人，其中 552 人正在积极随访，363 人已经去世，273 人进行了尸检。该研究队列建立了一个包含不断更新的详细临床、神经心理学、神经影像学和病理学信息的大型数据库。本文描述了该研究队列的历史、人口统计学、临床观察和病理学特征。我们还解释了一些不断发展的方法学以及由于这群积极的肯塔基老年人而取得的学术贡献。
