Department of Chemistry, Periyar University, Salem 636 011, Tamil Nadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:131-4. doi: 10.1016/j.saa.2012.02.033. Epub 2012 Mar 16.
Hydroxyapatite (HAP) is the main inorganic component of bone material and is widely used in various biomedical applications due to its excellent bioactivity and biocompatibility. In this paper, we have reported the synthesis of hydroxyapatite nanoparticles by a novel ultrasonic assisted mixed template directed method. In this method glycine-acrylic acid (GLY-AA) hollow spheres were used as an organic template which could be prepared by mixing of glycine with acrylic acid. The as-synthesized HAP nanoparticles were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and tunnelling electron microscope (TEM) to investigate the nature of bonding, crystallinity, size and shape. The thermal stability of as-synthesized nanoparticles was also investigated by the thermo gravimetric analysis (TGA). The effect of ultrasonic irradiation time on the crystallinity and size of the HAP nanoparticles in presence of glycine-acrylic acid hollow spheres template were investigated. From the inspection of the above results it is confirmed that the crystallinity and size of the HAP nanoparticles decrease with increasing ultrasonic irradiation time. Hence the proposed synthesis strategy provides a facile pathway to obtain nano sized HAP with high quality, suitable size and morphology.
羟基磷灰石（HAP）是骨材料的主要无机成分，由于其优异的生物活性和生物相容性，被广泛应用于各种生物医学应用中。在本文中，我们报道了一种通过新型超声辅助混合模板导向法合成羟基磷灰石纳米粒子的方法。在该方法中，甘氨酸-丙烯酸（GLY-AA）空心球被用作有机模板，该模板可通过甘氨酸与丙烯酸混合制备。通过 X 射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和隧道电子显微镜（TEM）对合成的 HAP 纳米粒子进行了表征，以研究键合、结晶度、尺寸和形状的性质。通过热重分析（TGA）还研究了合成纳米粒子的热稳定性。考察了在甘氨酸-丙烯酸空心球模板存在下，超声辐照时间对 HAP 纳米粒子结晶度和尺寸的影响。从上述结果的检查中可以确认，随着超声辐照时间的增加，HAP 纳米粒子的结晶度和尺寸减小。因此，所提出的合成策略为获得高质量、合适尺寸和形态的纳米级 HAP 提供了一种简便的途径。
