Burdett House, Mile End Hospital, London, UK.
J Psychopharmacol. 2012 May;26(5 Suppl):42-51. doi: 10.1177/0269881112442016. Epub 2012 Apr 2.
Hyperprolactinaemia is a common side effect of antipsychotics; markedly raised levels are less common. Higher levels of prolactin result from longer exposure to higher doses, especially with older antipsychotics or with risperidone, sulpiride or amisulpride. Galactorrhoea, gynaecomastia, menstrual abnormalities and sexual dysfunction including hypogonadism and fertility problems are consequences of raised prolactin, and in the longer-term bone demineralisation. Younger patients may be more susceptible to hyperprolactinaemia. Trial reports often fail to state the frequency of raised levels.
高催乳素血症是抗精神病药物的常见副作用；明显升高的催乳素水平则较为少见。催乳素水平升高是由于更长时间暴露于更高剂量，尤其是使用较老的抗精神病药物或利培酮、舒必利或氨磺必利。高催乳素血症的后果包括溢乳、乳腺增生、月经异常和性功能障碍，包括性腺功能减退和生育问题，长期还会导致骨质减少。年轻患者可能更容易发生高催乳素血症。临床试验报告往往没有说明催乳素水平升高的频率。
