Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Exp Cell Res. 2012 Jul 15;318(12):1407-20. doi: 10.1016/j.yexcr.2012.03.015. Epub 2012 Mar 24.
The Chromosomal Passenger Complex (CPC) consisting of Aurora B kinase, INCENP, Survivin and Borealin, is essential for genomic stability by controlling multiple processes during both nuclear and cytoplasmic division. In mitosis it ensures accurate segregation of the duplicated chromosomes by regulating the mitotic checkpoint, destabilizing incorrectly attached spindle microtubules and by promoting the axial shortening of chromosomal arms in anaphase. During cytokinesis the CPC most likely prevents chromosome damage by imposing an abscission delay when a chromosome bridge connects the two daughter cells. Moreover, by controlling proper cytoplasmic division, the CPC averts tetraploidization. This review describes recent insights on how the CPC is capable of conducting its various functions in the dividing cell to ensure chromosomal stability.
由 Aurora B 激酶、INCENP、Survivin 和 Borealin 组成的染色质乘客复合物（CPC）通过在核和细胞质分裂过程中控制多个过程，对于基因组稳定性至关重要。在有丝分裂中，它通过调节有丝分裂检查点、使不正确连接的纺锤体微管不稳定以及在后期促进染色体臂的轴向缩短，确保复制染色体的准确分离。在胞质分裂过程中，当染色体桥连接两个子细胞时，CPC 很可能通过施加胞质分裂延迟来防止染色体损伤。此外，通过控制适当的细胞质分裂，CPC 避免了四倍体化。本文综述了 CPC 如何在分裂细胞中发挥其各种功能以确保染色体稳定性的最新见解。
