Centre for Advanced Macromolecular Design, University of New South Wales, Sydney, Australia.
Chem Commun (Camb). 2012 May 16;48(39):4695-7. doi: 10.1039/c2cc30510k. Epub 2012 Apr 4.
Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells.
通过对 RAFT 糖基聚合物进行后修饰，制备了具有糖配体的金配合物脱乙酰金诺芬的聚合物版本。含有悬垂 Au(I)单元的嵌段共聚物的胶束化产生了纳米颗粒，对 OVCAR-3 人卵巢癌细胞的增殖抑制作用增强。
