Division de Physiopathologie Clinique, Département de Médecine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
J Hypertens. 2012 Jun;30(6):1161-8. doi: 10.1097/HJH.0b013e328352abf9.
To evaluate the impact of body position on the arterial stiffness indices provided by radial applanation tonometry in pregnant and nonpregnant women.
Twenty-four young women (18-30 years) in the third trimester of a normal pregnancy and 20 healthy nonpregnant women of the same age were enrolled. In each, applanation tonometry was carried out in the sitting and supine position. The following stiffness indices were analyzed: systolic augmentation index (sAix), sAix adjusted for heart rate (sAix@75) and diastolic augmentation index (dAix), all expressed in % of central aortic pulse pressure.
The sAix was apparently not influenced by body position, but the transition from seated to supine was associated with a substantial decrease in heart rate. When correcting for this confounder by calculating the sAix@75, systolic augmentation was substantially lower when individuals were supine (mean ± SD: nonpregnant 3.0 ± 14.4%, pregnant 8.8 ± 9.7%) than when they were sitting (nonpregnant 5.7 ± 13.0%, pregnant 11.1 ± 83%, P = 0.005 supine vs. seated in both study groups, P > 0.2 for pregnant vs. nonpregnant). The influence of body position on the dAix went in the opposite direction (supine: nonpregnant 9.7 ± 6.6%, pregnant 4.4 ± 3.5%; seated: nonpregnant 7.7 ± 5.8%, pregnant 3.3 ± 2.4%, P < 0.00001 supine vs. seated in both study groups, P = 0.001 for pregnant vs. nonpregnant).
Body position has a major impact on the pattern of central aortic pressure augmentation by reflected waves in healthy young women examined either during third trimester pregnancy or in the nonpregnant state.
评估体位对经桡动脉平板压力测量技术所测动脉僵硬度指数的影响，该技术在孕妇和非孕妇中均可应用。
共纳入 24 名处于孕晚期（18-30 岁）的年轻孕妇和 20 名年龄匹配的健康非孕妇。在两种体位（坐立位和仰卧位）下均进行平板压力测量。分析的僵硬度指数包括：收缩期增强指数（sAix）、心率校正的收缩期增强指数（sAix@75）和舒张期增强指数（dAix），均以中心动脉脉搏压的百分比表示。
sAix 似乎不受体位影响，但从坐立位到仰卧位时心率明显下降。通过计算 sAix@75 校正该混杂因素后，仰卧位时收缩期增强明显低于坐立位（非孕妇分别为 3.0%±14.4%和 5.7%±13.0%，孕妇分别为 8.8%±9.7%和 11.1%±83%，P=0.005，两组仰卧位均显著低于坐立位，P＞0.2，孕妇与非孕妇比较）。体位对 dAix 的影响则相反（仰卧位：非孕妇为 9.7%±6.6%和 7.7%±5.8%，孕妇为 4.4%±3.5%和 3.3%±2.4%，P＜0.00001，两组仰卧位均显著高于坐立位，P=0.001，孕妇与非孕妇比较）。
在健康年轻女性中，体位对反射波引起的中心动脉压力增强模式有很大影响，无论其处于孕晚期还是非孕期。
