Liu Gang, Swierczewska Magdalena, Lee Seulki, Chen Xiaoyuan
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892 USA.
Nano Today. 2010 Dec 1;5(6):524-539. doi: 10.1016/j.nantod.2010.10.005.
Gene therapy has great potential to bring tremendous changes in treatment of various diseases and disorders. However, one of the impediments to successful gene therapy is the inefficient delivery of genes to target tissues and the inability to monitor delivery of genes and therapeutic responses at the targeted site. The emergence of molecular imaging strategies has been pivotal in optimizing gene therapy; since it can allow us to evaluate the effectiveness of gene delivery noninvasively and spatiotemporally. Due to the unique physiochemical properties of nanomaterials, numerous functional nanoparticles show promise in accomplishing gene delivery with the necessary feature of visualizing the delivery. In this review, recent developments of nanoparticles for molecular imaging guided gene delivery are summarized.
基因治疗在引发各种疾病和病症治疗的巨大变革方面具有巨大潜力。然而，成功进行基因治疗的障碍之一是基因向靶组织的递送效率低下，以及无法在靶位点监测基因递送和治疗反应。分子成像策略的出现对于优化基因治疗至关重要；因为它能让我们在时空上非侵入性地评估基因递送的有效性。由于纳米材料独特的物理化学性质，众多功能性纳米颗粒在实现基因递送并具备可视化递送这一必要特性方面展现出前景。在本综述中，总结了用于分子成像引导基因递送的纳米颗粒的最新进展。
