Zeng Yun, Zhu Jing, Wang Junqing, Parasuraman Paramanantham, Busi Siddhardha, Nauli Surya M, Wáng Yì Xiáng J, Pala Rajasekharreddy, Liu Gang
Department of Pharmacology, Xiamen Medical College, Xiamen 361008, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Quant Imaging Med Surg. 2018 Sep;8(8):838-852. doi: 10.21037/qims.2018.09.19.
Cardiovascular diseases (CVDs) are a severely threatening disorder and frequently cause death in industrialized countries, posing critical challenges to modern research and medicine. Molecular imaging has been heralded as the solution to many problems encountered in individuals living with CVD. The use of probes in cardiovascular molecular imaging is causing a paradigmatic shift from regular imaging techniques, to future advanced imaging technologies, which will facilitate the acquisition of vital information at the cellular and molecular level. Advanced imaging for CVDs will help early detection of disease development, allow early therapeutic intervention, and facilitate better understanding of fundamental biological processes. To promote a better understanding of cardiovascular molecular imaging, this article summarizes the current developments in the use of molecular probes, highlighting some of the recent advances in probe design, preparation, and functional modification.
心血管疾病（CVDs）是一种严重威胁生命的疾病，在工业化国家经常导致死亡，给现代研究和医学带来了严峻挑战。分子成像被誉为解决CVD患者所面临诸多问题的方法。心血管分子成像中探针的使用正在引发从常规成像技术到未来先进成像技术的范式转变，这将有助于在细胞和分子水平获取重要信息。针对CVD的先进成像将有助于早期发现疾病发展，实现早期治疗干预，并促进对基本生物学过程的更好理解。为了促进对心血管分子成像的更好理解，本文总结了分子探针使用方面的当前进展，重点介绍了探针设计、制备和功能修饰方面的一些最新进展。
