Luo Qiao, Shao Ni, Zhang Ai-Chen, Chen Chun-Fang, Wang Duo, Luo Liang-Ping, Xiao Ze-Yu
The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Pharmaceuticals (Basel). 2023 Feb 7;16(2):249. doi: 10.3390/ph16020249.
New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes.
用于分子成像的新型纳米技术正被广泛应用于可视化特定分子（如离子、生物标志物）的表达，以用于疾病诊断。在各种纳米平台中，纳米酶在体内表现出类酶催化活性，由于其具有多种模拟酶活性、优异的生物相容性、易于表面修饰和低成本等独特性质，在分子成像中受到了极大的关注。此外，通过将具有超顺磁性、光声、荧光和光热性质的不同纳米颗粒整合在一起，纳米酶能够提高成像的灵敏度和准确性，以便更好地理解疾病的复杂性和生物学过程。此外，这些功能促使纳米酶作为治疗剂用于辅助治疗。在本综述中，我们重点关注纳米酶在分子成像中的应用，并讨论过氧化物酶（POD）、氧化酶（OXD）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）在不同成像模式下的应用。此外，还讨论了纳米酶在癌症治疗、细菌感染和炎症图像引导治疗中的应用。总体而言，本综述旨在为纳米技术和分子成像跨学科领域的研究提供完整的参考，以促进新型仿生纳米酶的发展和临床转化。
