Taylor Shelley E, Way Baldwin M, Welch William T, Hilmert Clayton J, Lehman Barbara J, Eisenberger Naomi I
Department of Psychology, University of California, Los Angeles, 90095, USA.
Biol Psychiatry. 2006 Oct 1;60(7):671-6. doi: 10.1016/j.biopsych.2006.04.019. Epub 2006 Aug 24.
Mixed evidence has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may be at increased risk for depression, if they have also been exposed to early or current adversity/stress. We address this debate by examining the relation of a stressful early family environment, recent adversity/stress, and the 5-HTTLPR to depressive symptomatology in a normal sample.
A nonclinical sample of 118 young adult men and women completed assessments of early family environment, recent stressful events, psychosocial resources, and psychological distress, including depressive symptomatology. The 5-HTTLPR was genotyped using a standard protocol with DNA extracted from oral fluid.
A stressful early family environment was significantly related to depressive symptomatology. In addition, gene-by-environment (GxE) interactions were observed between the 5-HTTLPR and both early family environment and current adversity/stress. Individuals homozygous for the short allele had greater depressive symptomatology if they had experienced early or recent adversity but significantly less depressive symptomatology if they reported a supportive early environment or recent positive experiences, compared with participants with the s/l or l/l genotype.
Early or current environment, in conjunction with the serotonin transporter polymorphism, predicts depressive symptomatology.
有混合证据表明，血清素转运体基因连锁多态性区域（5-HTTLPR）短等位基因（s/s）的纯合携带者，如果同时暴露于早期或当前的逆境/压力中，可能患抑郁症的风险会增加。我们通过研究正常样本中早期家庭环境压力、近期逆境/压力以及5-HTTLPR与抑郁症状之间的关系来解决这一争议。
118名年轻成年男女的非临床样本完成了对早期家庭环境、近期应激事件、心理社会资源以及心理困扰（包括抑郁症状）的评估。使用标准方案对从唾液中提取的DNA进行5-HTTLPR基因分型。
早期家庭环境压力与抑郁症状显著相关。此外，观察到5-HTTLPR与早期家庭环境和当前逆境/压力之间存在基因-环境（GxE）相互作用。与s/l或l/l基因型的参与者相比，短等位基因纯合个体如果经历过早期或近期逆境，则抑郁症状更严重，但如果报告有支持性的早期环境或近期积极经历，则抑郁症状明显较轻。
早期或当前环境，结合血清素转运体多态性，可预测抑郁症状。
