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Tales of a dirty drug: carbenoxolone, gap junctions, and seizures.

作者信息

Connors Barry W

出版信息

Epilepsy Curr. 2012 Mar;12(2):66-8. doi: 10.5698/1535-7511-12.2.66.

DOI:10.5698/1535-7511-12.2.66
PMID:22473546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3316363/
Abstract
摘要

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本文引用的文献

1
Role of gap junctions in epilepsy.缝隙连接在癫痫中的作用。
Neurosci Bull. 2011 Dec;27(6):389-406. doi: 10.1007/s12264-011-1944-1.
2
Electrical synapses control hippocampal contributions to fear learning and memory.电突触控制海马体对恐惧学习和记忆的贡献。
Science. 2011 Jan 7;331(6013):87-91. doi: 10.1126/science.1193785.
3
Direct actions of carbenoxolone on synaptic transmission and neuronal membrane properties.生胃酮对突触传递和神经元膜特性的直接作用。
J Neurophysiol. 2009 Aug;102(2):974-8. doi: 10.1152/jn.00060.2009. Epub 2009 Jun 17.
4
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies.间隙连接阻滞剂的特性及其行为、认知和电生理效应：动物和人体研究
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):181-98. doi: 10.1016/j.pnpbp.2008.12.014. Epub 2009 Jan 1.
5
Pyramid power: principal cells of the hippocampus unite!锥体束的力量：海马体的主要细胞联合起来！
Brain Cell Biol. 2006 Feb;35(1):5-11. doi: 10.1007/s11068-006-9004-x. Epub 2007 Mar 10.
6
Potent block of Cx36 and Cx50 gap junction channels by mefloquine.甲氟喹对Cx36和Cx50缝隙连接通道有强效阻断作用。
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12364-9. doi: 10.1073/pnas.0402044101. Epub 2004 Aug 5.
7
Electrical synapses in the mammalian brain.哺乳动物大脑中的电突触。
Annu Rev Neurosci. 2004;27:393-418. doi: 10.1146/annurev.neuro.26.041002.131128.
8
11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics.11β-羟基类固醇脱氢酶抑制可改善健康老年男性和2型糖尿病患者的认知功能。
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6734-9. doi: 10.1073/pnas.0306996101. Epub 2004 Apr 7.
9
Carbenoxolone inhibition of voltage-gated Ca channels and synaptic transmission in the retina.甘草次酸对视网膜电压门控钙通道及突触传递的抑制作用。
J Neurophysiol. 2004 Aug;92(2):1252-6. doi: 10.1152/jn.00148.2004. Epub 2004 Mar 17.
10
Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.甘草次酸对培养物中神经网络活动的阻断作用并非由其对缝隙连接的作用介导。
J Physiol. 2003 Dec 15;553(Pt 3):729-45. doi: 10.1113/jphysiol.2003.053439. Epub 2003 Sep 26.