Been Laura, Olar Adriana, Powers Martin P, López-Terrada Dolores, Lauririca Rodolfo
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Diagn Cytopathol. 2011 Oct;39(10):780-3. doi: 10.1002/dc.21553.
Myxoid liposarcoma is a subtype of liposarcoma with a predilection for the deep soft tissues of the extremities that accounts approximately for 10% of all adult soft tissue sarcomas. We report a case of a metastatic myxoid liposarcoma to the parotid gland, with fine-needle aspiration cytology correlation and molecular characterization. The lesion was diagnosed in a 53-year-old Hispanic male who presented with a left posterior thigh mass. A core needle biopsy established the diagnosis of myxoid liposarcoma. The patient underwent limb-sparing, wide local excision of the malignancy and later presented with an initial metastatic lesion to the parotid gland. The diagnosis of metastatic myxoid liposarcoma was rendered by fine-needle aspiration cytology with cell block preparation, and molecular confirmation. Although myxoid/round cell liposarcomas are classically described as having minimal pleomorphism on cytologic material, we encountered significant pleomorphism in our case. Therefore, a diagnosis of myxoid/round cell liposarcoma should still be a diagnostic consideration even if markedly pleomorphic cells are seen in fine-needle aspiration biopsies.
黏液样脂肪肉瘤是脂肪肉瘤的一种亚型，好发于四肢深部软组织，约占所有成人软组织肉瘤的10%。我们报告一例腮腺转移性黏液样脂肪肉瘤病例，并结合细针穿刺细胞学检查及分子特征进行分析。该病变发生于一名53岁的西班牙裔男性，患者最初表现为左大腿后部肿块。粗针活检确诊为黏液样脂肪肉瘤。患者接受了保肢的广泛局部恶性肿瘤切除术，随后出现腮腺初始转移病灶。通过细针穿刺细胞学检查及细胞块制备，并经分子学确认，诊断为转移性黏液样脂肪肉瘤。尽管黏液样/圆形细胞脂肪肉瘤在细胞学标本中通常表现为低度异型性，但我们的病例中出现了显著的异型性。因此，即使在细针穿刺活检中看到明显异型性的细胞，黏液样/圆形细胞脂肪肉瘤仍应作为诊断考虑之一。
