Endoscopy Unit, Nuovo Ospedale Civile S. Agostino Estense, Via Giardini 1355, Baggiovara, 41126 Modena, Italy.
Gastroenterol Res Pract. 2012;2012:493961. doi: 10.1155/2012/493961. Epub 2012 Mar 14.
Many endoscopic imaging modalities have been developed and introduced into clinical practice to enhance the diagnostic capabilities of upper endoscopy. In the past, detection of dysplasia and carcinoma of esophagus had been dependent on biopsies taken during standard white-light endoscopy (WLE). Recently high-resolution (HR) endoscopy enables us to visualize esophageal mucosa but resolution for glandular structures and cells is still low. Probe-based confocal laser endomicroscopy (pCLE) is a new promising diagnostic technique by which details of glandular and vascular structures of mucosal layer can be observed. However, the clinical utility of this new diagnostic tool has not yet been fully explored in a clinical setting. In this paper we will highlight this new technique for detection of esophageal dysplasia and carcinoma from a clinical practice perspective.
许多内镜成像方式已经被开发并引入临床实践，以提高上消化道内镜的诊断能力。过去，食管异型增生和癌的检测依赖于标准白光内镜（WLE）下的活检。最近，高分辨率（HR）内镜使我们能够观察食管黏膜，但对腺结构和细胞的分辨率仍然较低。基于探头的共聚焦激光内镜检查（pCLE）是一种新的有前途的诊断技术，通过该技术可以观察黏膜层的腺和血管结构的细节。然而，这种新的诊断工具在临床环境中的临床应用尚未得到充分探索。本文将从临床实践的角度强调这种新技术在检测食管异型增生和癌中的应用。
