University of Michigan, Life Sciences Institute, Ann Arbor, Michigan 48109, USA.
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a009357. doi: 10.1101/cshperspect.a009357.
Great progress has been made toward understanding the pathogenesis of Parkinson's disease (PD) during the past two decades, mainly as a consequence of the discovery of specific gene mutations contributing to the onset of PD. Recently, dysregulation of the autophagy pathway has been observed in the brains of PD patients and in animal models of PD, indicating the emerging role of autophagy in this disease. Indeed, autophagy is increasingly implicated in a number of pathophysiologies, including various neurodegenerative diseases. This article will lead you through the connection between autophagy and PD by introducing the concept and physiological function of autophagy, and the proteins related to autosomal dominant and autosomal recessive PD, particularly α-synuclein and PINK1-PARKIN, as they pertain to autophagy.
在过去的二十年中，人们对帕金森病（PD）的发病机制有了很大的了解，这主要是由于发现了导致 PD 发病的特定基因突变。最近，在 PD 患者的大脑和 PD 动物模型中观察到自噬途径的失调，表明自噬在这种疾病中的作用正在显现。事实上，自噬与许多病理生理学有关，包括各种神经退行性疾病。本文将通过介绍自噬的概念和生理功能，以及与常染色体显性和常染色体隐性 PD 相关的蛋白质，特别是α-突触核蛋白和 PINK1-PARKIN，来阐述自噬与 PD 之间的联系。
