Norley S G, Kraus G, Ennen J, Bonilla J, König H, Kurth R
Paul-Ehrlich-Institut, Langen, Federal Republic of Germany.
Proc Natl Acad Sci U S A. 1990 Nov;87(22):9067-71. doi: 10.1073/pnas.87.22.9067.
Potential reasons for the lack of pathogenicity of the simian immunodeficiency virus SIVagm in its natural host, the African green monkey (AGM, Cercopithecus aethiops), were investigated with respect to immunological mechanisms. The functional immune response of monkeys to infection was similar (though not identical) to that of humans to infection with human immunodeficiency virus type 1 (HIV-1). In the sera of infected animals, neutralizing antibodies were found to be low or absent, and in particular there was no neutralization of the various isolates by homologous sera. There was no detectable antibody/complement cytotoxicity, though AGM sera were able to initiate antibody-dependent cellular cytolysis of infected cells in the presence of healthy effector peripheral blood lymphocytes. As in the human/HIV system, macrophages from AGMs are readily infected by SIVagm. Two possibly important differences between the AGM/SIVagm system and the human/HIV system are (i) the low immune response of the AGMs to the core protein of SIVagm and (ii) the significantly lower inhibitory effect of SIVagm proteins on the proliferation of AGM lymphocytes.
针对免疫机制，研究了猿猴免疫缺陷病毒SIVagm在其天然宿主非洲绿猴（AGM，猕猴属埃塞俄比亚猕猴）中缺乏致病性的潜在原因。猴子对感染的功能性免疫反应与人类对1型人类免疫缺陷病毒（HIV-1）感染的反应相似（尽管不完全相同）。在受感染动物的血清中，发现中和抗体水平较低或不存在，特别是同源血清对各种分离株没有中和作用。虽然AGM血清在健康效应外周血淋巴细胞存在的情况下能够引发对感染细胞的抗体依赖性细胞溶解，但未检测到抗体/补体细胞毒性。与人类/HIV系统一样，AGM的巨噬细胞很容易被SIVagm感染。AGM/SIVagm系统与人类/HIV系统之间可能存在的两个重要差异是：（i）AGM对SIVagm核心蛋白的免疫反应较低；（ii）SIVagm蛋白对AGM淋巴细胞增殖的抑制作用明显较低。
