Nguyen Mai Ha Khoa, Nguyen Hai Xuan, Nguyen Mai Thanh Thi, Nguyen Nhan Trung
Faculty of Chemistry, University of Science, Vietnam National University, HoChiMinh City, Vietnam.
Nat Prod Commun. 2012 Feb;7(2):185-6.
From the MeOH extract of the heartwood of Artocapus altilis, thirteen phenolic compounds have been isolated, namely curcumin (1), desmethoxycurcumin (2), retrodihydrochalcone (3), apigenin (4), tangeretin (5), nobiletin (6), O-methyldehydrodieugenol (7), dehydrodieugenol (8), beta-hydroxypropiovanillone (9), p-coumaric acid (10), p-hydroxybenzaldehyde (11), vanillin (12), and vanillic acid (13). This is the first report on the presence of these compounds in the heartwood of A. altilis. Compounds 1, 2, and 10 showed more potent tyrosinase inhibitory activities, with IC50 values ranging from 2.3 to 42.0 microM, than the positive control kojic acid (IC50, 44.6 microM). The most active compound, p-coumaric acid (10) (IC50, 2.3 microM), was 22 times more active in tyrosinase inhibitory activity than kojic acid.
从面包树心材的甲醇提取物中，已分离出13种酚类化合物，即姜黄素（1）、去甲氧基姜黄素（2）、反式二氢查耳酮（3）、芹菜素（4）、橘红素（5）、川陈皮素（6）、O - 甲基脱氢二丁香酚（7）、脱氢二丁香酚（8）、β - 羟基苯丙香草酮（9）、对香豆酸（10）、对羟基苯甲醛（11）、香草醛（12）和香草酸（13）。这是关于这些化合物存在于面包树心材中的首次报道。化合物1、2和10表现出比阳性对照曲酸（IC50，44.6 microM）更强的酪氨酸酶抑制活性，IC50值范围为2.3至42.0 microM。活性最强的化合物对香豆酸（10）（IC50，2.3 microM）的酪氨酸酶抑制活性比曲酸高22倍。
