从海洋来源的芽孢链霉菌中分离出的一种新肽。
A new peptide isolated from a marine derived Streptomyces bacillaris.
作者信息
Hu Youcai, MacMillan John B
机构信息
Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines, Blvd, Dallas, TX 75390-9038, USA.
出版信息
Nat Prod Commun. 2012 Feb;7(2):211-4.
Abstract
A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.
摘要
从海洋沉积物来源的芽孢链霉菌培养物中分离出一种新的肽，L-O-乳酸-L-缬氨酸-D-O-羟基异戊酸-D-缬氨酸（1），它由D-缬氨酸、L-缬氨酸、L-乳酸和3-D-羟基异戊酸组成。通过一维、二维核磁共振和质谱分析确定了化合物1的平面结构。经过酸碱水解后，应用先进的马尔菲方法确定了1中缬氨酸残基的绝对构型，并通过基于莫舍尔试剂的高效液相色谱法确定了羟基酸单元的绝对构型。
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