Wake Masahiro, Hamada Yoshiki, Kumagai Kenichi, Tanaka Nobuho, Ikeda Yasuko, Nakatani Yasunori, Suzuki Ryuji, Fukui Naoshi
Department of Oral and Maxillofacial Surgery, Postgraduate School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Br J Oral Maxillofac Surg. 2013 Mar;51(2):164-9. doi: 10.1016/j.bjoms.2012.03.004. Epub 2012 Apr 2.
Our aim was to explore important inflammatory mediators for synovial chondromatosis in the temporomandibular joints (TMJs) by analysing synovial fluid. Samples were collected from 10 patients with unilateral synovial chondromatosis of the TMJ. Control samples were obtained from 11 subjects with no symptoms in the TMJ. Concentrations of aggrecan, interleukin (IL)-2, IL-4, IL-5, IL-6, IL-8 (CXCL8), IL-10, interferon (IFN)-γ, tumour necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF)-A were measured in the samples of synovial fluid, and the results in the two groups compared. The tissues from the affected TMJ were examined histologically and immunohistochemically. Of the proteins evaluated, the concentrations of aggrecan, IL-6, and VEGF-A were significantly higher in the group with synovial chondromatosis. The immunohistochemical analysis showed that the synovial cells around the osteocartilaginous nodules were vigorously expressing VEGF-A. IL-6 and VEGF-A are thought to have important roles in the pathology of synovial chondromatosis of the TMJ.
我们的目的是通过分析颞下颌关节（TMJ）滑膜液来探索滑膜软骨瘤病的重要炎症介质。从10例单侧TMJ滑膜软骨瘤病患者中采集样本。对照样本取自11例TMJ无症状的受试者。测定滑膜液样本中聚集蛋白聚糖、白细胞介素（IL）-2、IL-4、IL-5、IL-6、IL-8（CXCL8）、IL-10、干扰素（IFN）-γ、肿瘤坏死因子（TNF）-α和血管内皮生长因子（VEGF）-A的浓度，并比较两组结果。对患侧TMJ组织进行组织学和免疫组织化学检查。在所评估的蛋白质中，滑膜软骨瘤病组中聚集蛋白聚糖、IL-6和VEGF-A的浓度显著更高。免疫组织化学分析表明，骨软骨结节周围的滑膜细胞强烈表达VEGF-A。IL-6和VEGF-A被认为在TMJ滑膜软骨瘤病的病理过程中起重要作用。
