牛白血病血清中抗牛白血病病毒沉淀免疫球蛋白的异质性特性
Heterogeneous properties of BLV-precipitating immunoglobulins in bovine leukemic sera.
作者信息
Matthaeus W
出版信息
Ann Rech Vet. 1978;9(4):635-41.
Purified precipitating serum antibodies against bovine leukemia virus present in cattle suffering from various stages of leukosis were identified as immunoglobulins of the IgG 1 subclass and IgA class. Each of these precipitating immunoglobulins exhibited several electrical charges as well as molecular sizes the origin of which will be discussed. Differences in precipitating activities against antigen gp69 and p24 could be observed comparing serum from a suspect animal and a highly leukemic one. In disrupted BLV preparations four antigens were detected immunoelectrophoretically, and two of them could be analyzed. Antigen gp69 less basic than p24 showed a considerably faster mobility.
从患有不同阶段白血病的牛体内纯化出的抗牛白血病病毒沉淀血清抗体，被鉴定为IgG 1亚类和IgA类免疫球蛋白。这些沉淀免疫球蛋白中的每一种都表现出几种电荷以及分子大小，其来源将在后面讨论。比较疑似患病动物和高度白血病动物的血清，可以观察到针对抗原gp69和p24的沉淀活性存在差异。在破坏的牛白血病病毒制剂中，通过免疫电泳检测到四种抗原，其中两种可以进行分析。抗原gp69的碱性低于p24，其迁移速度明显更快。
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