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[牛白血病病毒的表达在成血细胞增多症发病机制中的作用]

[Role of the expression of the bovine leukemia virus in the pathogenesis of hemoblastoses].

作者信息

Konycheva V V, Il'inskaia T N, Chapenko S V, Laganovskiĭ S Ia

出版信息

Vopr Onkol. 1987;33(1):72-7.

PMID:3027992
Abstract

The role of bovine leukemia virus (BLV) expression was demonstrated in normal, BLV-infected and leukemic cattle. The studies established the changeable character of viremia on the basis of BLV p24 expression in blood plasma and native leukocyte lysates. The experiment revealed a marked regularity: a decrease of antibody titer in blood serum--the appearance of the virus in the body--lymphocytosis. The development of lympholeukemia shortly after experimental infection was detected in animals with an antigen regularly detectable in the plasma.

摘要

牛白血病病毒(BLV)表达在正常、感染BLV的牛和患白血病的牛中的作用得到了证实。这些研究基于血浆和天然白细胞裂解物中BLV p24的表达确定了病毒血症的可变特征。实验揭示了一个显著规律:血清抗体滴度降低——病毒在体内出现——淋巴细胞增多。在血浆中可定期检测到抗原的动物中,实验感染后不久就检测到了淋巴白血病的发展。

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