National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
Rheumatol Int. 2013 Mar;33(3):587-92. doi: 10.1007/s00296-012-2398-0. Epub 2012 Apr 3.
Analysis of the effect of psychosocial factors and co-morbidities on the health status of patients with chronic nonspecific low back pain and patients with surgical intervention because of disk herniation was performed. One hundred and two nonselected consecutive inpatients with chronic nonspecific low back pain were included in the study. Their average age was 56.7 (SD = 10.9) years. The control group consisted of 199 subjects matched according to age and sex, chosen from the database of the national representative health survey Hungarostudy 2006, which involved 4,527 subjects. We measured quality of life including mental health with the SF-36 questionnaire validated for use in Hungary, the short 9-item version of the Beck Depression Inventory, the WHO-Five Well-Being Index, and the Hospital Anxiety-Depression Scale. We characterized the socio-demographic status with variables on age, sex, marital status, and education. Data on symptoms and signs of low back pain, other musculoskeletal diseases, and their treatments including spinal surgery were recorded. Co-morbidity and body mass index were considered as independent indicators of health. Depression as measured by Beck Depression Inventory and severity of depression did not vary significantly according to marital status, education, hypertension, diabetes, and gastrointestinal disease. Only half of the patients (52 %) were in the normal range of the scale; 22 % suffered from mild, 16 % from moderate, and 12 % from severe depression. Average values for anxiety and depression as measured by Hospital Anxiety-Depression Scale and Beck Depression Inventory were both significantly higher in the patient than in the control group (Hospital Anxiety Scale: p = 0.0001; Beck Depression Inventory: p = 0.0001). According to the WHO Well-Being Index-5 scale, the difference between patients and the control group was significant (p = 0.0001). Furthermore, correlation was found between the incidence of depression and surgery. Depression was demonstrated in 47.4 % of those patients who had no surgery, in 50 % of patients who had one round of surgery, and in 62.5 % of those who had undergone surgery more than once; the contingence coefficient was 0.211. According to different measurements, the psychological state of patients with chronic nonspecific low back pain was significantly altered as compared to the matched Hungarian population. Higher anxiety and depression markers occurred in 48 % of the patients. There was no correlation between the depression of patients with low back pain and variables such as marital status, education, and co-morbidities. Our study is the first to demonstrate that depression runs parallel with the number of surgical procedures. Therefore, if there is a relative indication for surgery, depression and severity of depression should be assessed and considered when deciding on the intervention.
对慢性非特异性下腰痛患者和因椎间盘突出症接受手术治疗的患者的社会心理因素和合并症对健康状况的影响进行了分析。研究纳入了 102 名未经选择的慢性非特异性下腰痛连续住院患者。他们的平均年龄为 56.7(SD=10.9)岁。对照组由 199 名年龄和性别匹配的受试者组成,他们是从 2006 年全国代表性健康调查 Hungarostudy 的数据库中选择的,该数据库涉及 4527 名受试者。我们使用匈牙利验证的 SF-36 问卷、贝克抑郁量表的简短 9 项版本、世界卫生组织幸福感量表和医院焦虑抑郁量表来衡量包括心理健康在内的生活质量。我们用年龄、性别、婚姻状况和教育等变量来描述社会人口统计学状况。记录下腰痛和其他肌肉骨骼疾病的症状和体征以及包括脊柱手术在内的治疗情况。合并症和体重指数被视为健康的独立指标。贝克抑郁量表测量的抑郁和抑郁严重程度与婚姻状况、教育、高血压、糖尿病和胃肠道疾病无关。只有一半的患者(52%)在量表的正常范围内;22%的患者患有轻度抑郁,16%的患者患有中度抑郁,12%的患者患有重度抑郁。使用医院焦虑抑郁量表和贝克抑郁量表测量的焦虑和抑郁的平均值在患者组中均显著高于对照组(医院焦虑量表:p=0.0001;贝克抑郁量表:p=0.0001)。根据世界卫生组织幸福感量表-5 量表,患者组与对照组之间的差异具有统计学意义(p=0.0001)。此外,还发现抑郁的发生与手术有关。未接受手术的患者中有 47.4%患有抑郁,接受过一轮手术的患者中有 50%患有抑郁,接受过多次手术的患者中有 62.5%患有抑郁;列联系数为 0.211。根据不同的测量方法,与匹配的匈牙利人群相比,慢性非特异性下腰痛患者的心理状态发生了显著变化。48%的患者出现了更高的焦虑和抑郁标志物。下腰痛患者的抑郁与婚姻状况、教育程度和合并症等变量之间无相关性。我们的研究首次表明,抑郁与手术次数平行。因此,如果有相对的手术指征,在决定干预措施时,应评估和考虑抑郁和抑郁严重程度。