Lechler P, Handel M, Anders S, Balakrishnan S, Grifka J
Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum, Kaiser-Karl-V.-Allee 3, 93077, Bad Abbach, Deutschland.
Orthopade. 2012 Apr;41(4):260-7. doi: 10.1007/s00132-011-1852-0.
Survivin, the smallest member of the inhibitor of the apoptosis protein gene family (IAP) is a key molecule for mammalian cell cycle regulation and cellular survival. Of note these functions have been thought to be limited to embryonic and malignant tissues. However, a growing body of evidence indicates a limited expression of survivin in some highly specific adult tissues and cells. In the present study it has been demonstrated that the antiapoptotic protein survivin is re-expressed in osteoarthritic human cartilage and primary human chondrocytes. Furthermore, the data indicated that survivin significantly affects cell cycle regulation and cellular survival. The modulation of survivin expression and function in cartilaginous tissues might be important for understanding osteoarthritis and the development of regenerative strategies.
存活素是凋亡抑制蛋白基因家族（IAP）中最小的成员，是哺乳动物细胞周期调控和细胞存活的关键分子。值得注意的是，这些功能一直被认为仅限于胚胎组织和恶性组织。然而，越来越多的证据表明存活素在一些高度特异性的成体组织和细胞中表达有限。在本研究中，已证明抗凋亡蛋白存活素在骨关节炎患者的软骨和原代人软骨细胞中重新表达。此外，数据表明存活素显著影响细胞周期调控和细胞存活。软骨组织中存活素表达和功能的调节可能对理解骨关节炎和再生策略的发展具有重要意义。
