Olbert P J, Heinis J, Hofmann R, Hegele A
Klinik für Urologie und Kinderurologie, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Baldingerstraße, 35033 Marburg.
Urologe A. 2012 Jun;51(6):843-7. doi: 10.1007/s00120-012-2830-9.
Overdiagnosis and resulting overtreatment in prostate cancer are under intensive discussion both in the urologic communities and in the public media. Sensitive and specific diagnostic modalities could be one step forward to overcome this problem. Choline PET/CT provides fusion imaging that combines anatomical/morphological information with metabolic/functional data. Despite promising preclinical data and interesting initial clinical results, this cost-intensive and logistically demanding technology has not yet found its way into routine clinical practice; the German and European guideline recommendations are careful and reluctant. This review has the goal to give an overview of the recent data both on initial diagnosis and on staging/diagnosis for biochemical recurrence by choline PET/CT and to summarize the possible role of this innovative technology in the future, if adequate research projects can be realized.
前列腺癌的过度诊断及由此导致的过度治疗在泌尿外科领域和大众媒体中都受到了广泛讨论。灵敏且特异的诊断方法可能是解决这一问题的关键一步。胆碱PET/CT提供了融合成像，它将解剖学/形态学信息与代谢/功能数据相结合。尽管有前景良好的临床前数据和引人关注的初步临床结果，但这项成本高昂且在后勤方面要求较高的技术尚未进入常规临床实践；德国和欧洲的指南建议都较为谨慎且有所保留。这篇综述旨在概述胆碱PET/CT在初始诊断以及生化复发分期/诊断方面的最新数据，并总结如果能够开展足够的研究项目，这项创新技术在未来可能发挥的作用。
