Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899-8392, USA.
Anal Bioanal Chem. 2012 Nov;404(9):2683-92. doi: 10.1007/s00216-012-5943-5. Epub 2012 Apr 4.
Standard reference materials (SRMs) are homogeneous, well-characterized materials used to validate measurements and improve the quality of analytical data. The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have mass fraction values assigned for legacy pollutants. These SRMs can also serve as test materials for method development, method validation, and measurement for contaminants of emerging concern. Because inter-laboratory comparison studies have revealed substantial variability of measurements of perfluoroalkyl acids (PFAAs), future analytical measurements will benefit from determination of consensus values for PFAAs in SRMs to provide a means to demonstrate method-specific performance. To that end, NIST, in collaboration with other groups, has been measuring concentrations of PFAAs in a variety of SRMs. Here we report levels of PFAAs and perfluorooctane sulfonamide (PFOSA) determined in four biological SRMs: fish tissue (SRM 1946 Lake Superior Fish Tissue, SRM 1947 Lake Michigan Fish Tissue), bovine liver (SRM 1577c), and mussel tissue (SRM 2974a). We also report concentrations for three in-house quality-control materials: beluga whale liver, pygmy sperm whale liver, and white-sided dolphin liver. Measurements in SRMs show an array of PFAAs, with perfluorooctane sulfonate (PFOS) being the most frequently detected. Reference and information values are reported for PFAAs measured in these biological SRMs.
标准参考物质（SRM）是均匀、特征明确的材料，用于验证测量结果并提高分析数据的质量。美国国家标准与技术研究院（NIST）拥有广泛的 SRM，这些 SRM 具有分配给传统污染物的质量分数值。这些 SRM 还可以用作方法开发、方法验证和新兴关注污染物测量的测试材料。由于实验室间比较研究表明全氟烷基酸（PFAAs）的测量存在很大的可变性，因此未来的分析测量将受益于确定 SRM 中 PFAAs 的共识值，以提供一种方法来证明特定方法的性能。为此，NIST 与其他团体合作，一直在测量各种 SRM 中 PFAAs 和全氟辛烷磺酸（PFOSA）的浓度。在这里，我们报告了在四种生物 SRM 中测定的 PFAAs 和全氟辛烷磺酸（PFOSA）的水平：鱼组织（SRM 1946 苏必利尔湖鱼组织，SRM 1947 密歇根湖鱼组织）、牛肝（SRM 1577c）和贻贝组织（SRM 2974a）。我们还报告了三种内部质量控制材料的浓度：白鲸肝、小抹香鲸肝和白鳍豚肝。在 SRM 中的测量显示出一系列 PFAAs，其中全氟辛烷磺酸盐（PFOS）是最常检测到的。报告了这些生物 SRM 中测量的 PFAAs 的参考和信息值。
