Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
J Am Soc Mass Spectrom. 2012 Jun;23(6):1062-70. doi: 10.1007/s13361-012-0352-8. Epub 2012 Apr 3.
Surface acoustic wave nebulization (SAWN) has recently been reported as a novel method to transfer non-volatile analytes directly from solution to the gas phase for mass spectrometric analysis. Here we present a comparison of the survival yield of SAWN versus electrospray ionization (ESI) produced ions. A series of substituted benzylpyridinium (BzPy) compounds were utilized to measure ion survival yield from which ion energetics were inferred. We also estimated bond dissociation energies using higher level quantum chemical calculations than previously reported for BzPy ions. Additionally, the effects on BzPy precursor ion survival of SAWN operational parameters such as inlet capillary temperature and solution flow-rate were investigated. Under all conditions tested, SAWN-generated BzPy ions displayed a higher tendency for survival and thus have lower internal energies than those formed by ESI.
表面声波雾化 (SAWN) 最近被报道为一种将非挥发性分析物从溶液直接转移到气相进行质谱分析的新方法。在这里，我们比较了 SAWN 与电喷雾电离 (ESI) 产生的离子的生存产量。一系列取代的苄基吡啶鎓 (BzPy) 化合物被用来测量离子的生存产量，从中推断出离子的能量。我们还使用比以前报道的 BzPy 离子更高水平的量子化学计算来估计键离解能。此外，还研究了 SAWN 操作参数（如入口毛细管温度和溶液流速）对 BzPy 前体离子生存的影响。在所有测试的条件下，SAWN 产生的 BzPy 离子表现出更高的生存趋势，因此比 ESI 产生的离子具有更低的内能。
