Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala 695 581, India.
Biol Trace Elem Res. 2012 Oct;149(1):71-7. doi: 10.1007/s12011-012-9401-1. Epub 2012 Apr 5.
Diabetes is one of the leading causes of death in developed and developing countries. Oxidative stress has been proposed to play a crucial role in the pathogenesis of diabetic vascular complications. In recent years, selenium has been shown to mediate a number of insulinlike actions in a dose-dependent fashion both in vitro and in vivo. In this study, the effect of selenium as sodium selenite was investigated in streptozotocin-induced diabetic rats at the dose of 1 μg sodium selenite/kg body weight. Selenium supplementation restored the streptozotocin-induced alterations in the activities of antioxidant enzymes, decreased the serum glucose level, glycated hemoglobin content as well as the levels of lipid peroxidation products, and downregulated the expressions of both NFkB and RAGE. The histopathological studies also reinforce our findings. Hence, selenium has a protective role in streptozotocin-induced diabetes mellitus.
糖尿病是发达国家和发展中国家的主要死亡原因之一。氧化应激被认为在糖尿病血管并发症的发病机制中起关键作用。近年来，硒已被证明在体外和体内以剂量依赖的方式介导多种胰岛素样作用。在这项研究中，研究了亚硒酸钠作为硒的剂量为 1μg 亚硒酸钠/公斤体重的链脲佐菌素诱导的糖尿病大鼠中的作用。硒补充恢复了链脲佐菌素诱导的抗氧化酶活性的改变，降低了血清葡萄糖水平、糖化血红蛋白含量以及脂质过氧化产物的水平，并下调了 NFkB 和 RAGE 的表达。组织病理学研究也加强了我们的发现。因此，硒在链脲佐菌素诱导的糖尿病中具有保护作用。
