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1
Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient.环丙沙星在一名美沙酮依赖患者中诱发尖端扭转型室性心动过速。
Addiction. 2008 Dec;103(12):2062-4. doi: 10.1111/j.1360-0443.2008.02390.x.
2
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.CYP3A4、CYP2C8和CYP2D6在体外对（R）-和（S）-美沙酮代谢中的作用。
Drug Metab Dispos. 2003 Jun;31(6):742-7. doi: 10.1124/dmd.31.6.742.
3
Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.美沙酮临床药代动力学的个体间变异性：对阿片类药物依赖治疗的影响。
Clin Pharmacokinet. 2002;41(14):1153-93. doi: 10.2165/00003088-200241140-00003.
4
Methadone, ciprofloxacin, and adverse drug reactions.
Lancet. 2000 Dec 16;356(9247):2069-70. doi: 10.1016/S0140-6736(00)03409-7.
5
When "enough" is not enough: new perspectives on optimal methadone maintenance dose.当“足够”并不足够时：美沙酮维持治疗最佳剂量的新视角
Mt Sinai J Med. 2000 Oct-Nov;67(5-6):404-11.
6
Neuromuscular blockade after clindamycin administration: a case report.克林霉素给药后发生的神经肌肉阻滞：一例病例报告。
J Oral Maxillofac Surg. 1999 May;57(5):600-3. doi: 10.1016/s0278-2391(99)90083-6.
7
Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.
Drug Metab Dispos. 1996 Oct;24(10):1134-8.
8
Clindamycin-induced neuromuscular blockade.
Can J Anaesth. 1995 Jul;42(7):614-7. doi: 10.1007/BF03011880.
9
Overview of drug interactions with the quinolones.喹诺酮类药物相互作用概述。
J Antimicrob Chemother. 1988 Sep;22 Suppl C:97-107. doi: 10.1093/jac/22.supplement_c.97.
10
Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro.喹诺酮类抗菌剂在体内和体外对细胞色素P450IA2活性的抑制效力。
Antimicrob Agents Chemother. 1992 May;36(5):942-8. doi: 10.1128/AAC.36.5.942.

Interaction between Methadone and Ciprofloxacin.

作者信息

Samoy Leslie, Shalansky Karen F

机构信息

, BSc(Pharm), ACPR, is a Clinical Pharmacist-Orthopedics, Pharmaceutical Sciences CSU, Vancouver General Hospital, Vancouver, British Columbia.

出版信息

Can J Hosp Pharm. 2010 Sep;63(5):382-4. doi: 10.4212/cjhp.v63i5.950.

DOI:10.4212/cjhp.v63i5.950
PMID:22479006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2999370/
Abstract
摘要