Hîncu Sorina, Apetroaei Miruna-Maria, Ștefan Gabriela, Fâcă Anca Ionela, Arsene Andreea Letiția, Mahler Beatrice, Drăgănescu Doina, Tăerel Adriana-Elena, Stancu Emilia, Hîncu Lucian, Zamfirescu Andreea, Udeanu Denisa Ioana
Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6, Traian Vuia Street, 020956 Bucharest, Romania.
Fundeni Clinical Institute, 258, Fundeni Street, 022328 Bucharest, Romania.
Pharmaceutics. 2024 Aug 28;16(9):1137. doi: 10.3390/pharmaceutics16091137.
Prevention, assessment, and identification of drug-drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessment of the most clinically significant DDIs for antibiotics used in healthcare-associated infections. Complex poly-pharmaceutical regimens, targeting multiple pathogens or targeting one pathogen in the presence of another comorbidity, have an increased predisposition to result in life-threatening DDIs. Recognising, assessing, and limiting DDIs in nosocomial infections offers promising opportunities for improving health outcomes. The objective of this review is to provide clinicians with practical advice to prevent or mitigate DDIs, with the aim of increasing the safety and effectiveness of therapy. DDI management is of significant importance for individualising therapy according to the patient, disease status, and associated comorbidities.
药物相互作用（DDIs）的预防、评估和识别对医护人员来说是一项挑战，尤其是在医院环境中。本叙述性综述旨在全面评估医疗相关感染中使用的抗生素的最具临床意义的药物相互作用。针对多种病原体或在存在其他合并症的情况下针对一种病原体的复杂多药治疗方案，导致危及生命的药物相互作用的倾向增加。认识、评估和限制医院感染中的药物相互作用为改善健康结局提供了有前景的机会。本综述的目的是为临床医生提供预防或减轻药物相互作用的实用建议，以提高治疗的安全性和有效性。药物相互作用管理对于根据患者、疾病状态和相关合并症进行个体化治疗至关重要。
