阿尔茨海默病中与抑郁症相关的因素与其他痴呆症中发现的因素不同。
Factors associated with a depressive disorder in Alzheimer's disease are different from those found for other dementia disorders.
作者信息
Barca Maria Lage, Engedal Knut, Laks Jerson, Selbaek Geir
机构信息
Norwegian Centre for Dementia Research, Centre for Ageing and Health, Department of Geriatric Medicine, Oslo University Hospital, Ullevål, Norway.
出版信息
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):19-28. doi: 10.1159/000335775. Epub 2012 Feb 3.
BACKGROUND
This study explores factors associated with depression in Alzheimer's disease (AD) compared with mild cognitive impairment (MCI) and other dementia disorders.
METHOD
In a prospective study we included 195 patients: 31 with MCI, 112 with AD and 52 with other dementias.
RESULTS
According to the ICD-10 and the DSM-IV criteria, 88 (44.1%) and 59 (30.3%), respectively, had a depressive disorder. An adjusted multiple regression analysis showed that previous depression (p < 0.05) was significantly associated with depression in AD patients. Severity of dementia (p < 0.05) was significantly associated with a depressive disorder in a group of patients with frontotemporal dementia, vascular dementia, or dementia due to Lewy Body disease or Parkinson's disease.
CONCLUSION
We found different factors associated with a depressive disorder in AD compared to those found for other dementia disorders.
背景
本研究探讨与阿尔茨海默病（AD）相比，轻度认知障碍（MCI）和其他痴呆症患者中抑郁症的相关因素。
方法
在一项前瞻性研究中，我们纳入了195名患者：31名患有MCI，112名患有AD，52名患有其他痴呆症。
结果
根据国际疾病分类第10版（ICD - 10）和精神疾病诊断与统计手册第4版（DSM - IV）标准，分别有88名（44.1%）和59名（30.3%）患有抑郁症。经调整的多元回归分析显示，既往抑郁症（p < 0.05）与AD患者的抑郁症显著相关。在一组额颞叶痴呆、血管性痴呆、路易体病或帕金森病所致痴呆患者中，痴呆严重程度（p < 0.05）与抑郁症显著相关。
结论
我们发现，与其他痴呆症患者相比，AD患者中与抑郁症相关的因素有所不同。
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