Safi Najibullah, Davis Gary D, Nadir Mohammed, Hamid Hamida, Robert Leon L, Case Alan J
Primary Health Care Department, World Health Organization Country Office, UNOCA Compound, Jalalabad Road, Kabul, Islamic Republic of Afghanistan.
Mil Med. 2012 Mar;177(3):345-51. doi: 10.7205/milmed-d-11-00161.
Anthroponotic cutaneous leishmaniasis (CL) is a common cause of ulcerative lesions and disfiguring scarring among children in Afghanistan. Most lesions occur on the face and are commonly caused by the trypanosome protozoan parasite Leishmania tropica, transmitted by the bite of an infected sandfly (Phlebotomus sergenti). This study compared the effectiveness of a single localized treatment with thermotherapy to 5 days of intralesional administration of Glucantime for the treatment of CL. Three hundred and eighty-two patients with CL were randomly assigned to the two treatment groups and followed for 6 months. The cure rate for the thermotherapy group was 82.5%, compared to 74% in the Glucantime group. The authors concluded that a single localized treatment with thermotherapy was more effective than 5 days of intralesional administration of Glucantime. Additionally, thermotherapy was more cost-effective, with fewer side effects, of shorter duration, and with better patient compliance than intralesional Glucantime.
人源性皮肤利什曼病（CL）是阿富汗儿童溃疡性病变和毁容性瘢痕的常见病因。大多数病变发生在面部，通常由热带利什曼原虫这种锥虫原生动物寄生虫引起，通过受感染白蛉（ Sergenti 白蛉）叮咬传播。本研究比较了热疗单一局部治疗与5天病灶内注射葡糖胺锑钠治疗CL的效果。382例CL患者被随机分配到两个治疗组，并随访6个月。热疗组的治愈率为82.5%，而葡糖胺锑钠组为74%。作者得出结论，热疗单一局部治疗比5天病灶内注射葡糖胺锑钠更有效。此外，与病灶内注射葡糖胺锑钠相比，热疗更具成本效益，副作用更少，疗程更短，患者依从性更好。
