Marcucci L
Divisione ORL, Ospedale Grande degli Infermi di Viterbo.
Acta Otorhinolaryngol Ital. 1990;10 Suppl 28:73-86.
A multicenter trial is presented involving 39 Italian university and hospital centers and 1186 patients (mean age 37.6 +/- 0.46 years) suffering from phlogistic aural (33.7%), rhino-sinusal (22.5%) or pharyngolaryngeal (43.8%) pathology. These patients were treated with 600 mg of tiaprofenic acid daily for a period of 7 days. The drug was administered either as monotherapy (53.2% of the cases) or in association with antibiotics (46.8%). Tiaprofenic acid showed similar therapeutic efficacy under both conditions, carrying out a clear antipyretic, anti-inflammatory, mainly analgesic action in the pathologies of all three otolaryngological areas. Treatment tolerance and compliance proved quite good. Only 20% of the patients claimed light side effects. The treatment was interrupted only in 18 (1.5%) of the 1186 patients studied.
本文介绍了一项多中心试验，该试验涉及39个意大利大学和医院中心以及1186名患者（平均年龄37.6±0.46岁），他们患有炎性耳部疾病（33.7%）、鼻-鼻窦疾病（22.5%）或咽喉疾病（43.8%）。这些患者每天服用600毫克噻洛芬酸，为期7天。药物给药方式为单一疗法（53.2%的病例）或联合抗生素（46.8%）。噻洛芬酸在两种情况下均显示出相似的治疗效果，在所有三个耳鼻喉科领域的疾病中均具有明显的解热、抗炎，主要是镇痛作用。治疗耐受性和依从性相当良好。只有20%的患者声称有轻微副作用。在1186名研究患者中，只有18名（1.5%）中断了治疗。
