Applied Organic Chemistry Department, National Research Centre, Dokki, 12622 Giza, Egypt.
Eur J Med Chem. 2012 Jun;52:263-8. doi: 10.1016/j.ejmech.2012.03.023. Epub 2012 Mar 23.
New pyrazolyl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolylthiazoles were synthesized through multi step reactions using 1-tolylyl-4-acetyl-5-methyl-1,2,3-triazole as a precursor. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 11b was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their antimicrobial activities and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested compounds 5a, 5c, 11b and 11c displayed excellent antimicrobial activity.
新型吡唑基-1,2,3-三唑和 1,2,3-三唑-4-基-吡唑基噻唑是通过多步反应合成的，使用 1-甲苯基-4-乙酰基-5-甲基-1,2,3-三唑作为前体。所有新合成的化合物都通过光谱和元素分析进行了表征。11b 的结构通过 X 射线晶体学研究得到了证实。新合成的化合物进行了抗菌活性评价，对大多数测试生物进行了最低抑菌浓度（MIC）测定。在所测试的化合物中，5a、5c、11b 和 11c 表现出优异的抗菌活性。
