Genitourinary Oncology and Rare Cancer Center, Federico II University, Naples, Italy.
Anticancer Drugs. 2012 Jun;23(5):573-7. doi: 10.1097/CAD.0b013e328350ead7.
Guidelines on the treatment of metastatic squamous cell carcinoma of the penis are limited to a few prospective trials. Cisplatin-based regimens represent the standard of treatment with promising activity of taxanes. Recently, epidermal growth factor receptor overexpression has been shown in these patients. We treated an elderly man with a docetaxel-cetuximab combination after failure of the cisplatin regimen. We observed a necrosis of the inguinal lymph nodes and a reduction of (18)F-fluorodeoxyglucose uptake at PET/CT scan. Only mild mucositis and skin toxicity had been detected. Our case report, the first in the literature, shows that this combination is active and well tolerated in penile squamous cell carcinoma.
转移性阴茎鳞状细胞癌的治疗指南仅限于少数前瞻性试验。以顺铂为基础的方案是治疗标准，紫杉烷类药物具有良好的疗效。最近，这些患者中表皮生长因子受体过度表达。我们在顺铂方案失败后，用多西紫杉醇联合西妥昔单抗治疗了一位老年男性。我们观察到腹股沟淋巴结坏死和 PET/CT 扫描中（18）F-氟脱氧葡萄糖摄取减少。仅检测到轻微的黏膜炎和皮肤毒性。我们的病例报告是文献中的首例，表明该联合方案在阴茎鳞状细胞癌中具有活性且耐受性良好。
