Gillen R, Hesselbrock V
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030.
Alcohol Clin Exp Res. 1992 Apr;16(2):206-14. doi: 10.1111/j.1530-0277.1992.tb01365.x.
Previous research has suggested that individuals with a family history of alcoholism may have cognitive deficits that predate, and possibly predispose, to the onset of alcoholism. However, these deficiencies may result from other factors, e.g., comorbid psychopathology. The current study investigated the neuropsychological functioning of young adult males at high risk for alcohol abuse due to a family history of alcoholism (FH) and/or a personal history of antisocial personality disorder (ASP). A family history of alcoholism (FH+) alone was not associated with neuropsychological impairment. Subjects with ASP, however, exhibited some difficulty with higher level motor control and with verbal concept formation compared with nonASP subjects. No clear pattern of FH x ASP interaction was evident in the measures examined. These findings suggest that previous findings suggesting cognitive deficiencies in FH+ individuals may have been related to a failure to consider co-morbid ASP. The deficits exhibited by the ASP subjects may reflect both reduced inhibitory control and a deficiency in higher level verbal skills. These deficiencies may leave ASP individuals less capable of utilizing higher level language skills to regulate behavior.
先前的研究表明，有酗酒家族史的个体可能存在认知缺陷，这些缺陷先于酗酒发作，甚至可能是酗酒发作的诱因。然而，这些缺陷可能是由其他因素导致的，例如共病的精神病理学问题。本研究调查了因酗酒家族史（FH）和/或反社会人格障碍（ASP）个人史而有酗酒高风险的年轻成年男性的神经心理功能。仅酗酒家族史（FH+）与神经心理损伤无关。然而，与非ASP受试者相比，患有ASP的受试者在高级运动控制和言语概念形成方面表现出一些困难。在所检查的测量中，没有明显的FH×ASP相互作用模式。这些发现表明，先前关于FH+个体存在认知缺陷的研究结果可能与未考虑共病的ASP有关。ASP受试者表现出的缺陷可能既反映了抑制控制能力的下降，也反映了高级言语技能的不足。这些缺陷可能使ASP个体更难以利用高级语言技能来调节行为。
