Departments of Internal Medicine and Gastroenterology, Colentina University Hospital, Bucharest, Romania.
J Investig Med. 2012 Jun;60(5):827-9. doi: 10.2310/JIM.0b013e31825148b1.
Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 may be associated with involuntary weight loss in patients with and without cancer. However, results of previous studies have been conflicting. We evaluated patients who had involuntary weight loss to determine cytokine levels and the correlation of these cytokines with weight loss, the association with inflammation, and the potential for use in cancer diagnosis.
In 290 consecutive patients with involuntary weight loss (74 patients [26%] with cancer and 216 patients [74%] without cancer), erythrocyte sedimentation rate (ESR), and serum levels of C-reactive protein, TNF-α, IL-1β, and IL-6 were determined.
Higher ESR and levels of C-reactive protein, TNF-α, IL-1β, and IL-6 were associated with cancer. The levels of TNF-α, IL-1β, and IL-6 did not correlate with the amount of weight loss. In multivariable analysis, only ESR was associated with cancer.
In patients with involuntary weight loss, TNF-α, IL-1β, and IL-6 were associated with cancer but were not weight loss mediators.
肿瘤坏死因子-α（TNF-α）、白细胞介素 1β（IL-1β）和白细胞介素 6 可能与癌症患者和非癌症患者的非自愿性体重减轻有关。然而，先前的研究结果存在矛盾。我们评估了患有非自愿性体重减轻的患者，以确定细胞因子水平以及这些细胞因子与体重减轻的相关性、与炎症的相关性以及在癌症诊断中的潜在用途。
在 290 例连续的非自愿性体重减轻患者（74 例[26%]癌症患者和 216 例[74%]非癌症患者）中，测定红细胞沉降率（ESR）和血清 C 反应蛋白、TNF-α、IL-1β 和 IL-6 水平。
较高的 ESR 和 C 反应蛋白、TNF-α、IL-1β 和 IL-6 水平与癌症相关。TNF-α、IL-1β 和 IL-6 的水平与体重减轻的量无关。在多变量分析中，只有 ESR 与癌症相关。
在非自愿性体重减轻的患者中，TNF-α、IL-1β 和 IL-6 与癌症相关，但不是体重减轻的介质。
