中性粒细胞CD64作为新生儿败血症的诊断标志物
Neutrophil CD64 as a diagnostic marker in neonatal sepsis.
作者信息
Streimish Iris, Bizzarro Matthew, Northrup Veronika, Wang Chao, Renna Sara, Koval Nancy, Li Fang-Yong, Ehrenkranz Richard, Rinder Henry M, Bhandari Vineet
机构信息
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Pediatr Infect Dis J. 2012 Jul;31(7):777-81. doi: 10.1097/INF.0b013e318256fb07.
Abstract
We assessed neutrophil CD64 as a diagnostic marker for neonatal sepsis. For early-onset sepsis, the CD64 index with a cut-point value of 2.38 had sensitivity, specificity and negative predictive values of 100%, 68% and 100%, respectively. For late-onset sepsis, the respective values were 3.62, 75%, 77% and 96%. Neutrophil CD64 index can be incorporated as a valuable marker for excluding neonatal sepsis.
摘要
我们评估了中性粒细胞CD64作为新生儿败血症的诊断标志物。对于早发型败血症，CD64指数的切点值为2.38时，其敏感性、特异性和阴性预测值分别为100%、68%和100%。对于晚发型败血症，相应的值分别为3.62、75%、77%和96%。中性粒细胞CD64指数可作为排除新生儿败血症的有价值标志物。
相似文献
1
Neutrophil CD64 as a diagnostic marker in neonatal sepsis.中性粒细胞CD64作为新生儿败血症的诊断标志物
Pediatr Infect Dis J. 2012 Jul;31(7):777-81. doi: 10.1097/INF.0b013e318256fb07.
2
Neutrophil CD64 expression: a sensitive diagnostic marker for late-onset nosocomial infection in very low birthweight infants.中性粒细胞CD64表达：极低出生体重儿晚发性医院感染的敏感诊断标志物。
Pediatr Res. 2002 Mar;51(3):296-303. doi: 10.1203/00006450-200203000-00006.
3
Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early- and late-onset neonatal sepsis.评估中性粒细胞CD64、白细胞介素10和降钙素原作为早发型和晚发型新生儿败血症的诊断标志物。
Scand J Infect Dis. 2010 Apr;42(4):299-305. doi: 10.3109/00365540903449832.
4
Ratios of CD64 expressed on neutrophils, monocytes, and lymphocytes may be a novel method for diagnosis of neonatal sepsis.中性粒细胞、单核细胞和淋巴细胞上表达的CD64比值可能是诊断新生儿败血症的一种新方法。
J Infect Dev Ctries. 2015 Feb 19;9(2):175-81. doi: 10.3855/jidc.4992.
5
Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis.中性粒细胞 CD64 结合血液学标准用于诊断新生儿败血症。
Am J Perinatol. 2014 Jan;31(1):21-30. doi: 10.1055/s-0033-1334453. Epub 2013 Mar 1.
6
Diagnostic utility of neutrophil CD64 as a marker for early-onset sepsis in preterm neonates.中性粒细胞CD64作为早产儿早发型败血症标志物的诊断效用
PLoS One. 2014 Jul 17;9(7):e102647. doi: 10.1371/journal.pone.0102647. eCollection 2014.
7
Neutrophil CD64 as a diagnostic marker of sepsis in neonates.中性粒细胞 CD64 作为新生儿脓毒症的诊断标志物。
J Investig Med. 2014 Mar;62(3):644-9. doi: 10.2310/JIM.0000000000000060.
8
Neutrophil CD64 as a sepsis biomarker.中性粒细胞 CD64 作为脓毒症生物标志物。
Biochem Med (Zagreb). 2011;21(3):282-90. doi: 10.11613/bm.2011.038.
9
Predictive values of neutrophil CD64 expression compared with interleukin-6 and C-reactive protein in early diagnosis of neonatal sepsis.中性粒细胞 CD64 表达与白细胞介素-6 和 C 反应蛋白在新生儿败血症早期诊断中的预测价值。
J Clin Lab Anal. 2010;24(6):363-70. doi: 10.1002/jcla.20370.
10
Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection.中性粒细胞CD64是早发型新生儿感染的敏感诊断标志物。
Pediatr Res. 2004 Nov;56(5):796-803. doi: 10.1203/01.PDR.0000142586.47798.5E. Epub 2004 Sep 15.
引用本文的文献
1
Evaluation of whole blood CD64 for identifying infection in neonates receiving hospital care.评估全血CD64用于识别接受住院治疗的新生儿感染情况。
Front Immunol. 2025 Aug 18;16:1629223. doi: 10.3389/fimmu.2025.1629223. eCollection 2025.
2
Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis.白细胞介素-6（IL-6）作为晚发型新生儿败血症重要生物标志物的诊断准确性：一项更新的系统评价和荟萃分析
Eur J Pediatr. 2025 Sep 2;184(9):587. doi: 10.1007/s00431-025-06409-w.
3
Developing Augmented Pro-SOFA and Pro-SAPS Models by Integrating Biomarkers PCT, NLR, and CRP with SOFA and SAPS-III Scores.通过整合生物标志物降钙素原（PCT）、中性粒细胞与淋巴细胞比值（NLR）和C反应蛋白（CRP）与序贯器官衰竭评估（SOFA）及简化急性生理学评分III（SAPS-III）来开发增强型SOFA和SAPS模型。
Indian J Crit Care Med. 2024 Oct;28(10):935-941. doi: 10.5005/jp-journals-10071-24807. Epub 2024 Sep 30.
4
The Neutrophil: Constant Defender and First Responder.中性粒细胞：恒定的防御者和第一反应者。
Front Immunol. 2020 Sep 24;11:571085. doi: 10.3389/fimmu.2020.571085. eCollection 2020.
5
Neutrophil CD64 index in cerebrospinal fluid as a marker of bacterial ventriculitis in children with external ventricular drainage.脑脊液中性粒细胞 CD64 指数作为伴有外部脑室引流的儿童细菌性脑室炎的标志物。
BMC Pediatr. 2019 Apr 25;19(1):132. doi: 10.1186/s12887-019-1497-4.
6
Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease.急性胰腺炎患者中调节性B细胞水平降低：与疾病严重程度的关联。
Oncotarget. 2018 Jan 3;9(90):36067-36082. doi: 10.18632/oncotarget.23911. eCollection 2018 Nov 16.
7
[CD64 index as a marker of infection in patients with postoperative fever].[CD64指数作为术后发热患者感染的标志物]
Rev Esp Quimioter. 2018 Dec;31(6):493-498. Epub 2018 Oct 31.
8
Could Neutrophil CD64 Expression Be Used as a Diagnostic Parameter of Bacteremia in Patients with Febrile Neutropenia?中性粒细胞CD64表达能否作为发热性中性粒细胞减少症患者菌血症的诊断参数？
Turk J Haematol. 2017 Jun 5;34(2):167-173. doi: 10.4274/tjh.2016.0123. Epub 2016 Jun 27.
9
Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis.中性粒细胞CD64对新生儿败血症诊断准确性的Meta分析。
Ital J Pediatr. 2016 Jun 7;42(1):57. doi: 10.1186/s13052-016-0268-1.
10
Could CD64 expression be used as a predictor of positive culture results in children with febrile neutropenia?CD64表达能否作为发热性中性粒细胞减少症患儿培养结果阳性的预测指标？
Rev Bras Hematol Hemoter. 2015 Nov-Dec;37(6):395-9. doi: 10.1016/j.bjhh.2015.08.011. Epub 2015 Oct 9.
本文引用的文献
1
Procalcitonin in detecting neonatal nosocomial sepsis.降钙素原在检测新生儿医院感染性败血症中的应用。
Arch Dis Child Fetal Neonatal Ed. 2012 Sep;97(5):F368-70. doi: 10.1136/fetalneonatal-2010-194100.
2
Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis.新生儿重症监护病房中抗生素的使用与坏死性小肠结肠炎的风险。
J Pediatr. 2011 Sep;159(3):392-7. doi: 10.1016/j.jpeds.2011.02.035. Epub 2011 Apr 13.
3
Predictive values of neutrophil CD64 expression compared with interleukin-6 and C-reactive protein in early diagnosis of neonatal sepsis.中性粒细胞 CD64 表达与白细胞介素-6 和 C 反应蛋白在新生儿败血症早期诊断中的预测价值。
J Clin Lab Anal. 2010;24(6):363-70. doi: 10.1002/jcla.20370.
4
Biomarkers for late-onset neonatal sepsis: cytokines and beyond.晚发型新生儿败血症的生物标志物：细胞因子及其他。
Clin Perinatol. 2010 Sep;37(3):599-610. doi: 10.1016/j.clp.2010.05.005.
5
Presumed and definite bacteremia in extremely low gestational age newborns.极早产儿疑似菌血症与明确菌血症。
Acta Paediatr. 2011 Jan;100(1):36-41. doi: 10.1111/j.1651-2227.2010.01963.x. Epub 2010 Aug 16.
6
International perspective on early-onset neonatal sepsis.国际视角下的早发性新生儿败血症。
Clin Perinatol. 2010 Jun;37(2):501-23. doi: 10.1016/j.clp.2010.02.004.
7
Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis.辅助实验室检查在早发型新生儿败血症诊断中的应用。
Clin Perinatol. 2010 Jun;37(2):421-38. doi: 10.1016/j.clp.2009.12.001.
8
CD64 cell surface expression on neutrophils for diagnosis of neonatal sepsis.中性粒细胞上CD64的细胞表面表达用于新生儿败血症的诊断。
Egypt J Immunol. 2008;15(2):53-61.
9
Sepsis biomarkers: a review.脓毒症生物标志物：综述。
Crit Care. 2010;14(1):R15. doi: 10.1186/cc8872. Epub 2010 Feb 9.
10
Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early- and late-onset neonatal sepsis.评估中性粒细胞CD64、白细胞介素10和降钙素原作为早发型和晚发型新生儿败血症的诊断标志物。
Scand J Infect Dis. 2010 Apr;42(4):299-305. doi: 10.3109/00365540903449832.
Zotero 插件