Department of Dermatology, Competence Center Chronic Pruritus, University Hospital Münster, Münster, Germany.
G Ital Dermatol Venereol. 2012 Apr;147(2):161-9.
Chronic pruritus is one of the most frequent complaints of the skin associated with a high disease burden and markedly impaired quality of life. Chronic pruritus (>6 weeks of duration) may occur in a broad variety of diseases including dermatological, systemic, neurological, psychosomatic/psychiatric and gynaecological ones and in every age group (children, adults, pregnant women, elderly patients). The medical care of patients with chronic pruritus has improved significantly in the past few years (14). Though research into the neurobiology of chronic pruritus has failed to resolve the mechanisms underlying this disease, it has led to the awareness that management of patients with chronic pruritus needs a separate strategy that is different from therapy of the underlying disease. The antipruritic therapy is still based on symptomatic regimens and target-specific therapies urgently needed.
慢性瘙痒是皮肤最常见的症状之一，它与高疾病负担和明显降低的生活质量有关。慢性瘙痒（持续时间超过 6 周）可能发生在多种疾病中，包括皮肤科、系统性、神经科、身心/精神病学和妇科疾病，并且发生在各个年龄段（儿童、成人、孕妇、老年患者）。过去几年中，慢性瘙痒患者的医疗护理得到了显著改善（14）。尽管对慢性瘙痒的神经生物学研究未能解决该疾病的发病机制，但它使人们意识到，慢性瘙痒患者的管理需要一种不同于基础疾病治疗的单独策略。止痒治疗仍然基于对症方案，迫切需要针对特定靶点的治疗方法。
