髓源性抑制细胞参与预防移植物排斥反应。
Myeloid-derived suppressor cells participate in preventing graft rejection.
作者信息
Wang Yan, Gu Xiaodong, Xiang Jianbin, Chen Zongyou
机构信息
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
出版信息
Clin Dev Immunol. 2012;2012:731486. doi: 10.1155/2012/731486. Epub 2012 Mar 15.
Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
摘要
髓系来源的抑制性细胞（MDSCs）是一类异质性细胞群体，具有强大的抑制免疫反应的潜力。在肿瘤进展、自身免疫、慢性感染、移植及其他病理状况下，MDSCs会积聚，并能有效抑制T细胞功能。在此，我们讨论描述MDSCs抑制T细胞免疫反应分子机制的最新研究发现，以及MDSCs可能在移植耐受中发挥作用的最新观察结果。
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