Wang Yan, Gu Xiaodong, Xiang Jianbin, Chen Zongyou
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Clin Dev Immunol. 2012;2012:731486. doi: 10.1155/2012/731486. Epub 2012 Mar 15.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
髓系来源的抑制性细胞（MDSCs）是一类异质性细胞群体，具有强大的抑制免疫反应的潜力。在肿瘤进展、自身免疫、慢性感染、移植及其他病理状况下，MDSCs会积聚，并能有效抑制T细胞功能。在此，我们讨论描述MDSCs抑制T细胞免疫反应分子机制的最新研究发现，以及MDSCs可能在移植耐受中发挥作用的最新观察结果。
