Iglesias Pablo, Salas Antonio, Costoya Jose A
Commun Integr Biol. 2012 Jan 1;5(1):34-8. doi: 10.4161/cib.18160.
The main energetic resources of the cell are the mitochondria. As such, these organelles control a number of processes related to the life and death of the cell and also have a prominent function in the maintenance of tumor cells. In the last years, several authors have proposed an active role for mitochondria in tumorigenesis, more specifically concerning somatic mutations in mitochondrial DNA (mtDNA). Here, we wanted to evaluate this hypothesis based on the conclusions obtained in a model of gliomagenesis with elevated levels of ROS (reactive oxygen species), a toxic by-product of tumor metabolism. According to our findings, none of the mtDNA variants were found relevant to the tumoral process or suggest the involvement of mitochondria in tumorigenesis beyond the metabolic requirements of the tumoral cell. We conclude that there is not enough evidence to support the claim that mitochondrial instability holds any relevant role in the tumoral process.
细胞的主要能量来源是线粒体。因此，这些细胞器控制着许多与细胞生死相关的过程，并且在肿瘤细胞的维持中也发挥着重要作用。在过去几年中，几位作者提出线粒体在肿瘤发生中具有积极作用，更具体地说是关于线粒体DNA（mtDNA）的体细胞突变。在这里，我们想根据在具有高水平活性氧（ROS，肿瘤代谢的有毒副产物）的胶质瘤发生模型中获得的结论来评估这一假设。根据我们的研究结果，没有发现任何mtDNA变异与肿瘤过程相关，也没有表明线粒体除了肿瘤细胞的代谢需求之外还参与肿瘤发生。我们得出结论，没有足够的证据支持线粒体不稳定性在肿瘤过程中起任何相关作用的说法。
