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类风湿关节炎中听觉受累的临床意义:一项病例对照研究。

Clinical significance of auditive involvement in rheumatoid arthritis: a case-control study.

作者信息

Alonso Laura, Gutierrez-Farfan Ileana, Peña-Ayala Angelica, Perez-Bastidas Maria-Esther, Espinosa Rolando

机构信息

Audiology Department, Instituto Nacional de Rehabilitación, Avenida México-Xochimilco 289, Arenal de Guadalupe, Tlalpan, 14389 México City, Mexico.

出版信息

ISRN Rheumatol. 2011;2011:208627. doi: 10.5402/2011/208627. Epub 2011 Mar 20.

DOI:10.5402/2011/208627
PMID:22482066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3317080/
Abstract

Introduction. Rheumatoid arthritis (RA) can involve the incudomalleolar or incudostapedial articulations. Objective. To know the punctual prevalence of audiological alterations in patients with RA. Patients and Methods. RA patients and their controls (Cs), were evaluated by Tonal Audiometry (AU); if there were alterations in the air conduction (AC), bone conduction (BC), Logoaudiometry (LG), and Tympanometry (T) were performed. Results. 45 RA patients and 45 Cs were evaluated. RA patients had 40% of bilateral and 17.8% unilateral alteration versus Cs with 22.2% bilateral and 4.4% unilateral alteration versus Cs with 22.2% bilateral and 4.4% unilateral in AC audiometry. In conventional T (CT) As-type curves in patients with RA, there were 22 LE (48.8%) and 26 RE (57.7%) versus Cs, there were16 RE (35.5%) and 20 LE (44.4%). In High-frequency T (HFT): the 3B1G pattern in RA more frequent versus Controls (Cs) in RE (P = .002 and LE (P = .01). There were no differences according to RA activity or RA disease evolution. Conclusions. There is a greater tendency of auditive loss of As curves in CT (rigidity in ossicular chain) and of the 3B1G pattern in HFT in RA.

摘要

引言。类风湿性关节炎(RA)可累及砧镫关节或砧骨足板关节。目的。了解RA患者听力改变的时点患病率。患者与方法。对RA患者及其对照组(C组)进行纯音听力测试(AU);若气导(AC)、骨导(BC)、言语测听(LG)及鼓室导抗图(T)有改变,则进行相应检查。结果。共评估了45例RA患者和45例C组患者。在AC听力测试中,RA患者双侧改变占40%,单侧改变占17.8%,而C组双侧改变占22.2%,单侧改变占4.4%。在常规鼓室导抗图(CT)中,RA患者As型曲线左耳有22例(48.8%),右耳有26例(57.7%),而C组右耳有16例(35.5%),左耳有20例(44.4%)。在高频鼓室导抗图(HFT)中:RA患者右耳3B1G模式比对照组(C组)更常见(P = 0.002),左耳也更常见(P = 0.01)。根据RA活动度或RA疾病进展情况无差异。结论。RA患者在CT中As曲线(听骨链僵硬)听力损失倾向更大,在HFT中3B1G模式听力损失倾向更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/969da4ec0251/ISRN.RHEUMATOLOGY2011-208627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/fdf51acf67ec/ISRN.RHEUMATOLOGY2011-208627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/72e19ae88c39/ISRN.RHEUMATOLOGY2011-208627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/969da4ec0251/ISRN.RHEUMATOLOGY2011-208627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/fdf51acf67ec/ISRN.RHEUMATOLOGY2011-208627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/72e19ae88c39/ISRN.RHEUMATOLOGY2011-208627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/3317080/969da4ec0251/ISRN.RHEUMATOLOGY2011-208627.003.jpg

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Chloroquine ototoxicity.氯喹耳毒性。
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Ossicular Bone Damage and Hearing Loss in Rheumatoid Arthritis: A Correlated Functional and High Resolution Morphometric Study in Collagen-Induced Arthritic Mice.类风湿关节炎中的听小骨损伤与听力损失:胶原诱导性关节炎小鼠的功能与高分辨率形态学相关研究
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