诱导多能干细胞向肺内胚层分化。
Directing lung endoderm differentiation in pluripotent stem cells.
机构信息
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, 19104, USA.
出版信息
Cell Stem Cell. 2012 Apr 6;10(4):355-61. doi: 10.1016/j.stem.2012.03.013.
Abstract
The lung is composed of numerous epithelial lineages that arise from the anterior foregut endoderm. This review discusses how insights into the signaling mechanisms that regulate lung endoderm specification and subsequent differentiation have recently been exploited to direct differentiation of hESCs/iPSCs into expandable lung progenitors.
摘要
肺由从前肠内胚层产生的众多上皮谱系组成。这篇综述讨论了如何利用调控肺内胚层特化和随后分化的信号机制的见解，来指导 hESC/iPSC 向可扩增的肺祖细胞的分化。
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