Tunis S L, Golbus M S, Copeland K L, Fine B A, Rosinsky B J, Seely L
Department of Psychiatry, University of California, San Francisco 94143-0720.
Am J Med Genet. 1990 Oct;37(2):191-9. doi: 10.1002/ajmg.1320370207.
The purpose of this study was to compare patterns of self-reported mood states of women having chorionic villus sampling (CVS) (n = 151) to those of women electing amniocentesis (n = 30) with the indication of advanced maternal age. Mood states were defined as scores on the 6 subscales of the Profile of Mood States (POMS). Women at 4 U.S. prenatal diagnostic facilities completed the POMS at 4 assessment periods. These were a) at their initial genetic counseling session, b) 2 weeks post CVS results (or an equivalent time), c) 2 weeks post amniocentesis results (or an equivalent time), and d) at 30 weeks gestation. Repeated measures analysis of variance revealed that anxiety, fatigue, and confusion decreased, and vigor increased in both groups as the pregnancy progressed. Depression decreased in both groups and then increased at assessment 4 in women in the amniocentesis group but not in those electing CVS. Results should be interpreted in conjunction with obstetrically and genetically-oriented findings regarding safety and accuracy to help women decide between the 2 procedures.
本研究的目的是比较接受绒毛取样（CVS）的女性（n = 151）与因产妇年龄偏大而选择羊膜穿刺术的女性（n = 30）自我报告的情绪状态模式。情绪状态定义为情绪状态剖面图（POMS）6个分量表的得分。美国4家产前诊断机构的女性在4个评估阶段完成了POMS测试。这4个阶段分别为：a）在她们最初的遗传咨询阶段，b）绒毛取样结果出来后2周（或同等时间），c）羊膜穿刺术结果出来后2周（或同等时间），d）妊娠30周时。重复测量方差分析显示，随着妊娠进展，两组的焦虑、疲劳和困惑程度均下降，活力增加。两组的抑郁程度均下降，然后在羊膜穿刺术组的女性中，在第4次评估时增加，而选择绒毛取样的女性则没有。应结合有关安全性和准确性的产科及遗传学研究结果来解释这些结果，以帮助女性在这两种检查方法之间做出选择。
