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[免疫组织化学标志物在色素性结膜病变诊断中的应用]

[Immunohistochemical markers in the diagnosis of pigmented conjunctival lesions].

作者信息

Bellido Muñoz R M, Domínguez Hidalgo I, García Serrano J L, López Peña C

机构信息

Hospital Clínico San Cecilio, Granada, España.

出版信息

Arch Soc Esp Oftalmol. 2012 Apr;87(4):119-21. doi: 10.1016/j.oftal.2011.07.016. Epub 2011 Dec 29.

Abstract

OBJECTIVE/METHOD: The aim of this study was to assess the importance of immunohistochemical markers in the diagnosis of pigmented conjunctival lesions. Due to the difficulty of making an exact clinical diagnosis, the suspicion of malignancy requires the removal of the lesion and performing a histopathology study in which immunohistochemical markers may help to determine the nature of the lesion.

CASES REPORT/DISCUSSION: A case is presented of a 25 year-old woman with a pigmented lesion in the caruncle. It appeared recently and was growing fast with increasing pigmentation. Due to a suspicion of malignancy, the total lesion was removed. The microscopic study revealed cellular alterations which suggested malignancy. However, after carrying out immunohistochemical markers the diagnosis was conjunctival compound nevus.

摘要

目的/方法:本研究的目的是评估免疫组化标志物在色素性结膜病变诊断中的重要性。由于准确的临床诊断存在困难,怀疑为恶性病变时需要切除病变并进行组织病理学研究,其中免疫组化标志物可能有助于确定病变的性质。

病例报告/讨论:报告了一例25岁女性泪阜部色素性病变的病例。该病变近期出现,生长迅速且色素沉着增加。因怀疑为恶性病变,切除了整个病变。显微镜检查显示细胞改变提示为恶性。然而,进行免疫组化标志物检测后诊断为结膜复合痣。

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