从治疗银屑病的草药中分离并结构鉴定松香酸作为主要掺杂物。
Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis.
机构信息
National Institutes for Food and Drug Control, Tiantan Xili 2, Beijing 100050, China.
出版信息
J Pharm Biomed Anal. 2012 Jul;66:345-8. doi: 10.1016/j.jpba.2012.03.007. Epub 2012 Mar 23.
PMID:22482903
Abstract
An herbal drug for the treatment of psoriasis showed severe clinical adverse reactions. The main component of adulterant was isolated from the drug and its chemical structure was elucidated as abietic acid using NMR, HR-MS, and HPLC-DAD-MS. Although abietic acid had ever been used in clinical study for the treatment of psoriasis, it is not an approved drug. Its adulteration is very dangerous for the patients.
摘要
一种用于治疗银屑病的草药药物出现了严重的临床不良反应。掺杂物的主要成分从药物中分离出来，并用 NMR、HR-MS 和 HPLC-DAD-MS 阐明其化学结构为松香酸。尽管松香酸曾用于治疗银屑病的临床研究，但它不是一种批准的药物。其掺假对患者来说非常危险。
相似文献
1
Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis.从治疗银屑病的草药中分离并结构鉴定松香酸作为主要掺杂物。
J Pharm Biomed Anal. 2012 Jul;66:345-8. doi: 10.1016/j.jpba.2012.03.007. Epub 2012 Mar 23.
2
Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product.一种作为草药产品掺假物发现的他达拉非类似物的结构解析。
Food Addit Contam. 2006 May;23(5):446-51. doi: 10.1080/02652030500479690.
3
[Study on determination methods for abietic acid in fake Myrrha].[伪没药中松香酸测定方法的研究]
Zhong Yao Cai. 2012 Aug;35(8):1237-41.
4
Characterization of bixin by LC-MS and LC-NMR.通过液相色谱-质谱联用仪和液相色谱-核磁共振仪对胭脂树橙进行表征。
J Sep Sci. 2007 Oct;30(15):2382-90. doi: 10.1002/jssc.200700089.
5
Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.采用高效液相色谱-二极管阵列检测法（HPLC-DAD）和高效液相色谱-二极管阵列检测-质谱联用法（HPLC-DAD-MS）鉴定并定量分析欧前胡素（Peucedanum ostruthium （L.） Koch）中的香豆素。
J Agric Food Chem. 2011 May 11;59(9):4371-7. doi: 10.1021/jf104772x. Epub 2011 Mar 22.
6
A new abietic acid-type diterpene glucoside from the needles of Pinus densiflora.从赤松的针叶中分离得到一种新的枞酸型二萜糖苷。
Arch Pharm Res. 2009 Dec;32(12):1699-704. doi: 10.1007/s12272-009-2206-x. Epub 2010 Feb 17.
7
Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement.在一种草药膳食补充剂中检测到的西地那非新型类似物的结构解析，该类似物被用作掺假物。
J Pharm Biomed Anal. 2007 Apr 11;43(5):1615-21. doi: 10.1016/j.jpba.2006.11.037. Epub 2007 Jan 4.
8
Identification, isolation and characterization of potential degradation product in risperidone tablets.利培酮片中潜在降解产物的鉴定、分离与表征
J Pharm Biomed Anal. 2008 Jan 7;46(1):165-9. doi: 10.1016/j.jpba.2007.08.008. Epub 2007 Aug 14.
9
Phytochemistry in the microgram domain - a LC-NMR perspective.微克级别的植物化学——液相色谱-核磁共振视角
Magn Reson Chem. 2005 Sep;43(9):697-709. doi: 10.1002/mrc.1631.
10
The use of LC/MS, GC/MS, and LC/NMR hyphenated techniques to identify a drug degradation product in pharmaceutical development.在药物研发中使用液相色谱/质谱联用（LC/MS）、气相色谱/质谱联用（GC/MS）和液相色谱/核磁共振联用（LC/NMR）等联用技术来鉴定药物降解产物。
J Pharm Biomed Anal. 2006 Feb 24;40(3):581-90. doi: 10.1016/j.jpba.2005.08.020. Epub 2005 Oct 20.
引用本文的文献
1
Revealing the potential bioactive components and mechanism of Qianhua Gout Capsules in the treatment of gouty arthritis through network pharmacology, molecular docking and pharmacodynamic study strategies.通过网络药理学、分子对接和药效学研究策略揭示千花痛风胶囊治疗痛风性关节炎的潜在生物活性成分及作用机制。
Heliyon. 2024 May 10;10(10):e30983. doi: 10.1016/j.heliyon.2024.e30983. eCollection 2024 May 30.
2
A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges.营养保健品的全面综述：治疗支持和制剂挑战。
Nutrients. 2022 Nov 3;14(21):4637. doi: 10.3390/nu14214637.
3
Preparation of functionalized porous nano-γ-AlO powders employing colophony extract.采用松香提取物制备功能化多孔纳米γ-氧化铝粉末。
Biotechnol Rep (Amst). 2014 Jul 21;4:21-29. doi: 10.1016/j.btre.2014.07.001. eCollection 2014 Dec.
4
A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity.一种具有高效抗疟活性的非细胞毒性N-脱氢枞胺衍生物。
Exp Parasitol. 2015 Aug;155:68-73. doi: 10.1016/j.exppara.2015.05.002. Epub 2015 May 14.
Zotero 插件