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从治疗银屑病的草药中分离并结构鉴定松香酸作为主要掺杂物。

Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis.

机构信息

National Institutes for Food and Drug Control, Tiantan Xili 2, Beijing 100050, China.

出版信息

J Pharm Biomed Anal. 2012 Jul;66:345-8. doi: 10.1016/j.jpba.2012.03.007. Epub 2012 Mar 23.

DOI:10.1016/j.jpba.2012.03.007
PMID:22482903
Abstract

An herbal drug for the treatment of psoriasis showed severe clinical adverse reactions. The main component of adulterant was isolated from the drug and its chemical structure was elucidated as abietic acid using NMR, HR-MS, and HPLC-DAD-MS. Although abietic acid had ever been used in clinical study for the treatment of psoriasis, it is not an approved drug. Its adulteration is very dangerous for the patients.

摘要

一种用于治疗银屑病的草药药物出现了严重的临床不良反应。掺杂物的主要成分从药物中分离出来，并用 NMR、HR-MS 和 HPLC-DAD-MS 阐明其化学结构为松香酸。尽管松香酸曾用于治疗银屑病的临床研究，但它不是一种批准的药物。其掺假对患者来说非常危险。

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