一种作为草药产品掺假物发现的他达拉非类似物的结构解析。
Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product.
作者信息
Zou Peng, Hou Peiling, Low Min-Yong, Koh Hwee-Ling
机构信息
Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543.
出版信息
Food Addit Contam. 2006 May;23(5):446-51. doi: 10.1080/02652030500479690.
A tadalafil analogue and hydroxyhomosildenafil were isolated from a herbal product marketed for erectile dysfunction. The structure of the tadalafil analogue was elucidated using LC-UV, high resolution MS, ESI-MS/MS, IR, and NMR. The compound was determined to be (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dione. This compound should be included as a target compound when screening for adulterants in herbal products. This is the first published paper on a tadalafil analogue and hydroxyhomosildenafil found as adulterants of a herbal product.
从一种用于治疗勃起功能障碍的草药产品中分离出一种他达拉非类似物和羟基高同型西地那非。使用液相色谱 - 紫外光谱法、高分辨率质谱法、电喷雾串联质谱法、红外光谱法和核磁共振法阐明了该他达拉非类似物的结构。该化合物被确定为(6R,12aR)-2-氨基-6-(1,3-苯并二氧杂环戊烯-5-基)-2,3,6,7,12,12a-六氢吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-1,4-二酮。在筛查草药产品中的掺假物时，该化合物应作为目标化合物纳入。这是关于作为草药产品掺假物的他达拉非类似物和羟基高同型西地那非的首篇发表论文。
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