Reepmeyer John C, Woodruff Jeffrey T, d'Avignon D André
US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA.
J Pharm Biomed Anal. 2007 Apr 11;43(5):1615-21. doi: 10.1016/j.jpba.2006.11.037. Epub 2007 Jan 4.
A new analogue of sildenafil was detected in an herbal dietary supplement, which was sold over the internet and promoted as a product for the enhancement of sexual performance. The structure of the compound was established using LC-MS, UV spectroscopy, MS-MS, and NMR. In addition, the compound was cleaved at its sulfonamide S-N bond yielding a sulfonic acid and an amine, which were independently characterized using LC-MS, GC-MS, and derivatization. The compound, named methisosildenafil, is a novel synthetic analogue of sildenafil in which the N-methylpiperazine moiety has been replaced with 2,6-dimethylpiperazine.
在一种草药膳食补充剂中检测到一种新的西地那非类似物，该补充剂通过互联网销售，并被宣传为一种增强性功能的产品。使用液相色谱 - 质谱联用（LC-MS）、紫外光谱（UV）、串联质谱（MS-MS）和核磁共振（NMR）确定了该化合物的结构。此外，该化合物在其磺酰胺S-N键处裂解，生成磺酸和胺，分别使用LC-MS、气相色谱 - 质谱联用（GC-MS）和衍生化进行表征。该化合物名为甲磺酸异西地那非，是西地那非的一种新型合成类似物，其中N-甲基哌嗪部分已被2,6-二甲基哌嗪取代。
Zotero 插件