Demer J L, Holds J B, Hovis L A
Jules Stein Eye Institute, University of California, Los Angeles.
Am J Ophthalmol. 1990 Dec 15;110(6):674-82. doi: 10.1016/s0002-9394(14)77067-9.
In essential blepharospasm histopathologic and electrophysiologic evidence supports the existence of lesions in proximity to brainstem nuclei controlling ocular movements. We studied horizontal ocular movements in eight patients who had been treated previously with surgery or botulinum toxin injection to control essential blepharospasm (mean age, 58 years) and compared these with seven control subjects who did not have blepharospasm (mean age, 68 years). We examined fixation stability, saccades, the vestibulo-ocular reflex, visual enhancement and suppression of the vestibulo-ocular reflex, optokinetic nystagmus, and pursuit by using digitally sampled, direct current electro-oculography. Patients with blepharospasm exhibited no ocular movement abnormalities. Since quantitative aspects of ocular movements are sensitive to nonspecific brainstem lesions, the absence of abnormal ocular movements suggests that the lesion in blepharospasm is specifically limited to neurons regulating the facial muscles.
在原发性睑痉挛中，组织病理学和电生理学证据支持在控制眼球运动的脑干核附近存在病变。我们研究了8例曾接受手术或肉毒杆菌毒素注射以控制原发性睑痉挛的患者（平均年龄58岁）的水平眼球运动，并将其与7例无睑痉挛的对照受试者（平均年龄68岁）进行比较。我们使用数字采样的直流电眼震图检查了注视稳定性、扫视、前庭眼反射、视觉增强和前庭眼反射抑制、视动性眼震和跟踪。睑痉挛患者未表现出眼球运动异常。由于眼球运动的定量方面对非特异性脑干病变敏感，眼球运动无异常表明睑痉挛中的病变特别局限于调节面部肌肉的神经元。
