Scott Pauline L, Motaparthi Kiran, Krishnan Bhuvaneswari, Hsu Sylvia
Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Dermatol Online J. 2012 Mar 15;18(3):4.
Pyogenic granuloma-like Kaposi sarcoma (PG-like KS) is a clinicopathologic variant of Kaposi sarcoma (KS), a vascular tumor caused by human herpesvirus-8 (HHV-8). PG-like KS is a challenging entity to diagnose because its clinical and histological features encompass both pyogenic granuloma (PG) and KS characteristics. Immunhistochemical staining with HHV-8 latent nuclear antigen-1 (LNA-1) has been shown to exhibit high sensitivity and specificity for diagnosing KS. Therefore, the integration of clinical features and context, histopathogical findings, and immunohistochemical analysis is important in obtaining the correct diagnosis of PG-like KS. We report a case of PG-like KS in an HIV-positive man.
化脓性肉芽肿样卡波西肉瘤（PG样KS）是卡波西肉瘤（KS）的一种临床病理变体，KS是一种由人疱疹病毒8型（HHV-8）引起的血管肿瘤。PG样KS是一种诊断具有挑战性的实体，因为其临床和组织学特征兼具化脓性肉芽肿（PG）和KS的特点。已证明用HHV-8潜伏核抗原-1（LNA-1）进行免疫组化染色对诊断KS具有高敏感性和特异性。因此，综合临床特征与背景、组织病理学发现以及免疫组化分析对于正确诊断PG样KS很重要。我们报告一例HIV阳性男性的PG样KS病例。
