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聚磷酸钛钾激光是治疗化脓性肉芽肿的有效工具。对 28 例患者的回顾性研究。

A potassium-titanyl-phosphate laser is an efficacious tool in the treatment of pyogenic granulomas. A retrospective study in 28 patients.

机构信息

Department of Dermatology, Medical University of Vienna, Austria.

出版信息

Photochem Photobiol Sci. 2019 Feb 13;18(2):343-348. doi: 10.1039/c8pp00264a.

Abstract

BACKGROUND AND OBJECTIVE

Pyogenic granuloma is a common benign vascular lesion of the skin and mucosa prone to ulceration and bleeding. Current therapeutic approaches include surgical excision, removal by means of electro caustic therapy, cryotherapy, and ablation with CO2 or vascular lasers. The purpose of this study was to investigate the efficacy of a 532 nm potassium-titanyl-phosphate laser (KTP-laser) for the treatment of pyogenic granulomas in terms of efficacy, advantages in clinical outcome, technique and associated side effects.

METHODS

In this retrospective study we report on the response of 28 consecutive patients with pyogenic granulomas at multiple locations on the skin after having been treated with a 532 nm KTP laser (532 nm AuraTM Star Pulse laser, Laserscope, CA, USA). Treatment was performed with a 2 mm handpiece and energy fluences of 35-60 J cm-2 and a laser pulse width of 50 ms or with a 1 mm handpiece and energy fluences of 200-240 J cm-2 and a laser pulse width of 50 ms. All patients were treated on an outpatient basis at the department of dermatology, Medical University of Vienna, Austria.

RESULTS

In all of the 28 patients treated, we were able to demonstrate both symptomatic and clinical clearing of the lesions with excellent cosmetic results after the treatment. In 25 of the 28 patients a single treatment was sufficient to obtain optimal results. In three patients a second treatment session was required due to the recurrence of the lesion. The procedure required only local anesthesia, and postoperative care was limited to the application of a topical antibiotic ointment. No postoperative complications such as increased pain or wound infection and only minimal scarring were observed.

CONCLUSIONS

This experience with excellent patient satisfaction suggests that treatment of pyogenic granulomas with the KTP laser is a safe, effective, and reasonable alternative to conventional therapy. As with many other limited interventions with this laser technology, the advantages include minimal postoperative pain, conservative site-specific minimally invasive surgeries and a very satisfactory cosmetic result with a high acceptance rate on the side of the patients.

摘要

背景与目的

化脓性肉芽肿是一种常见的皮肤和黏膜良性血管性病变,容易发生溃疡和出血。目前的治疗方法包括手术切除、电灼、冷冻治疗、CO2 或血管激光消融。本研究旨在探讨 532nm 倍频钕钛磷酸钾(KTP)激光治疗化脓性肉芽肿的疗效,包括疗效、临床优势、技术和相关副作用。

方法

在这项回顾性研究中,我们报告了 28 例位于皮肤多个部位的化脓性肉芽肿患者接受 532nm KTP 激光(532nm AuraTM Star Pulse 激光,Laserscope,CA,美国)治疗后的反应。治疗使用 2mm 手具,能量密度为 35-60J/cm2,激光脉冲宽度为 50ms;或使用 1mm 手具,能量密度为 200-240J/cm2,激光脉冲宽度为 50ms。所有患者均在奥地利维也纳医科大学皮肤科接受门诊治疗。

结果

在所有接受治疗的 28 例患者中,我们均能观察到症状和临床改善,皮损清除良好,美容效果极佳。28 例患者中,25 例单次治疗即可获得最佳效果,3 例因皮损复发需要再次治疗。该治疗仅需局部麻醉,术后护理仅限于外用抗生素软膏。未观察到术后并发症,如疼痛加重或伤口感染,仅观察到轻微的瘢痕形成。

结论

本研究患者满意度高,表明 KTP 激光治疗化脓性肉芽肿是一种安全、有效、合理的替代传统治疗方法。与该激光技术的许多其他有限干预措施一样,其优点包括术后疼痛轻微、保守的针对特定部位的微创手术以及非常满意的美容效果,患者接受度高。

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