Gaertner Erich M, Switlyk Stephen A
SaraPath Diagnostics, Sarasota, Florida, USA.
Dermatol Online J. 2012 Mar 15;18(3):12.
Cutaneous granulomatous vasculitis associated with lymphoproliferative disorders is a rare entity, with only 14 cases previously reported in the English literature. Patients generally present with nodules or ulcers involving the extremities, which can appear months or years before or after onset of systemic disease. Granulomatous vasculitis has a poor prognosis when associated with underlying lymphoproliferative disorders, with the majority of reported cases fatal. Knowledge of this unusual entity is important to allow for proper clinical evaluation, follow-up, and therapy. We report a 77-year-old female with chronic lymphocytic leukemia and granulomatous vasculitis, which highlights the features of this association, and expands the clinical data.
与淋巴增殖性疾病相关的皮肤肉芽肿性血管炎是一种罕见的病症，英文文献中此前仅报道过14例。患者通常表现为累及四肢的结节或溃疡，这些症状可在全身性疾病发作前数月或数年出现，也可在发作后出现。当肉芽肿性血管炎与潜在的淋巴增殖性疾病相关时，预后较差，大多数报道的病例是致命的。了解这种不寻常的病症对于进行适当的临床评估、随访和治疗很重要。我们报告了一名患有慢性淋巴细胞白血病和肉芽肿性血管炎的77岁女性，这突出了这种关联的特征，并扩充了临床数据。
